2.  Data review  Risk factors and prevention  Secondary prevention

4.  1 st described by Hippocrates to describe radiating appendage-like projections observed in breast tumors › In Greek, cancer = crab  Def.: malignant tumor of potentially unlimited growth that expands locally by invasion and systemically by metastasis

5. global status report on noncommunicable diseases 2010

6. WWMR, December 9, 2011 / 60(48);1656-1656

7. global status report on noncommunicable diseases 2010

14. WWMR, December 9, 2011 / 60(48);1656-1656

16. From AACR Cancer Progress Report 2011 Colon cancer

17. 9/7/2004 Actual Causes of Death in the United States McGinnis JM, Foege WH. Actual causes of death in the United States. JAMA 1993; 270(18):2207-12.

18. Major recommendati on from World Cancer Research Fund and American Institute for Cancer Research (All?)

19. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

20. RESULTS: RR for 5 kg/m 2 BMI RR=1.18 (1.14, 1.21) Ning Y. et al. Obesity Review, 2009 20

21. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

22. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

23. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

24. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

25. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps /

26. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

27. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

28. Source: Mokdad A H, et al. J Am Med Assoc 1999;282:16, 2001;286:10. CDC Obesity Trends http://www.cdc.gov/nccdphp/dnpa/obesity/trend/maps/

31. Normal Epithelium Hyperproliferating Epithelium Early Adenoma Intermediate Adenoma Late Adenoma Carcinoma Metastasis Screening 30-40 years

32. Natural history of the disease Treatment is effective Reduce mortality

33.  1981 Doll and Peto compared incidence in countries or regions with the highest and lowest rates › Estimated majority of cancer due to preventable causes  ACS challenge goals (1996) to reduce mortality by 50% through 2015 9/7/2004