1. Outcomes Following Anterior Approach to Total Hip Arthroplasty: A Multi-Centre Observational Study The Anterior THA Collaborative

2. Investigative Team Anterior THA Research Collaborative Chair: Joel M. Matta MD, St. John’s Hospital, Santa Monica Secretary: Dave Dodgin MD, Walnut Creek, California Research: Mohit Bhandari MD, McMaster University, Canada Participating Surgeons: Gary Bradley MD, Santa Barbara, CA Jim Grimes MD, Bakersfield, CA John Masonis MD, Charlotte, NC Stefan Kreuzer MD, Houston, TX Andrew Yun MD, Inglewood, CA Gary Matthys MD, Fargo, ND Brian Jewett MD, Eugene,OR Michael Bellino MD, Palo Alto, CA

3. Funding DePuy –Research Grant Not involved in Protocol Development, Data Management, Data Analysis or Decision to Publish

4. Methods Multi-center cohort study of adult participants with hip arthritis All surgically treated with anterior approach THA

5. Sample Size To have sufficient sample size to conduct regression analyses exploring baseline variables association (N=10) with the presence or absence of complications, we require approximately 100 events (ie. 10 events per variable included in the analysis). Given a plausible complication rate of 10%, we will require atleast 1000 patients for our study

6. 9 Clinical Sites across United States 1152 Patients Included –125 bilateral THAs 1277 THAs RESULTS

7. Results Mean Age: 65 ± 12.2 years Median BMI26 %Female: 53% %Caucasian: 92% %Retired: 46% %Osteoarthritis 93% % Bilateral THA10%

8. Results Press-fit 94% 32mm head 50%

9. Results Median Follow Up: 1 year (max: 8 yrs) Hospital Stay –Median: 3 days –25% discharged by 2 days –80% discharged by 4 days Time to Discard Assistive Devices –Median 14 days

10. Results Dislocation Rate –0.6% (95%CI: 0.3%-1.2%)

11. Complications: Technique Overall Rate: 2.5% (95% CI: 2.0%-3.6%) –Greater Trochanteric Fracture 12 patients –Calcar split 7 patients –Femoral Shaft Fracture 8 patients –Infection 8 patients

12. Matta, J.M.; Anterior Approach for Total Hip Replacement: Background and Operative Technique; Chapter 8 pp121-140 in MIS Techniques in Orthopedics (Scuderi, G.R., Tria, A.J., Berger, R.A. editors); copyright Springer Science+Business Media, Inc. Matta, J.M.; Ferguson, T.A.: The Anterior Approach for Hip Replacement. Orthopedics, vol 28, no. 9; p. 927-928, September 2005. Yerasimides, J.G.; Matta, J.M.: Primary Total Hip Arthroplasty with a Minimally Invasive Anterior Approach. Seminars in Arthroplasty, vol 16, no.3, p. 186-190, September 2005. Matta, J.M.; Shahrdar, C.; Ferguson, T.: Single-Incision Anterior Approach for Total Hip Arthroplasty on an Orthopaedic Table. Clin Orthop Rel Res, no. 441, p 115-124, December 2005. Siguier, T.; Siguier, M.; Brumpt, B.: Mini-incision Anterior Approach does not increase dislocation rate. A study of 1037 Total Hip Replacements. Clin Orthop Rel Res, no. 426, p 164-171, 2004. Anterior THA References