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Maša Radeljak Mentor: A. Žmegač Horvat

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Presentation on theme: "Maša Radeljak Mentor: A. Žmegač Horvat"— Presentation transcript:

1 Maša Radeljak Mentor: A. Žmegač Horvat
TREATMENT OF TUMORS Maša Radeljak Mentor: A. Žmegač Horvat

2 GOALS OF TREATMENT Complete removal Palliation
Amelioration of symptoms Preservation of quality of life

3 TREATMENT OF TUMORS Surgery Radiation therapy Chemotherapy
Biologic therapy

4 TREATMENT OF TUMORS ADJUVANT Given after the primary treatment
Chemotherapy, radiation therapy, biologic therapy NEOADJUVANT First step before the main treatment Chemotherapy, radiation therapy

5 SURGERY Prevention- resection of premalignant lesions
Diagnosis- excisional biopsy, incisional biopsy, core-needle biopsy, fine-needle aspiration

6 SURGERY Staging- determining the extent of the disease and whether it has metastasized to regional lymph nodes

7 SURGERY - TREATMENT Most effective therapy 40% Complete excision
Local control of tumor Preservation of organ function Resection of metastatic disease Staging information Mastectomy, prostatectomy, lung cancer surgery

8 SURGERY Palliation- supportive care, pain management, insertion of central venous catheters, ascites Rehabilitation- breast reconstruction, orthopedic procedures

9 RADIATION THERAPY Target tissue Genetic material Free radicals Oxygen
X-rays and gamma rays Teletherapy, brachytherapy, systemic therapy with radionuclides

10 TELETHERAPY External beam radiotherapy Linear accelerators
Most commonly used form of radiation Breast, head and neck cancer, Hodgkin's disease

11 BRACHYTHERAPY Internal radiotherapy Inside or next to the tumor
Temporary or permanent Cervical, brain, skin and prostate cancer

12 CHEMOTHERAPY Cytotoxic drugs Rapidly dividing cells Alkylating agents
Antimetabolites Plant alkaloids and terpenoids Topoisomerase inhibitors Antitumor antibiotics Hormonal agents

13 TOXICITY Nausea Vomiting Myelosuppression Mucositis Alopecia
Gonadal dysfunction

14 BIOLOGIC THERAPY Immune mediators Antibodies Cytokines
Angiogenesis inhibitors

15 REFERENCES http://en.wikipedia.org/wiki/Cancer_treatm ent
Harrison: Principles of Internal Medicine


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