1. Be a Champion 2005 Workshop

2. Richard Higbee Vice President Global Marketing

3. Our Promise We promise you will leave with... A Clear Understanding of the Pharmanex Vision and Strategy A Conviction That Pharmanex Products Change Lives Key Message Points That Will Help You Build Your Business “Business Take-aways”

4. The Pharmanex Strategy Our strategy is to leverage science in order to create the most innovative sponsoring products in the dietary supplement and functional foods industry.

5. Michael Chang, Ph.D. President of Pharmanex Chief Scientific Advisor, Pharmanex Fellow Joseph Chang, Ph.D.

6. First Pharmanex office

7. Homestead

8. A Victory for Cholestin TM and 57 Million Americans Cholestin, Good News for Better Health. Here’s some very good news for the estimated 57 million Americans who want a safe and 100% natural way to promote and maintain healthy cholesterol levels* – Cholestin is not a drug. A recent federal court ruling said that Cholestin meets all criteria as a dietary supplement. This distinction means that you can continue to enjoy direct access to this remarkably effective product, giving you an extremely strong weapon in the fight for better health. Research Confirms Cholestin Works. Cholestin’s benefits have been supported by over 30 clinical studies, all of which produced impressive results. Most recently, a double-blind, placebo-controlled study of Cholestin’s patented form of red yeast rice, was conducted by the UCLA School of Medicine and published by the American Journal of Clinical Nutrition. The studies measured the effects on cholesterol levels before and after supplementation with Cholestin. It was proven that Cholestin was effective compared to the placebo group.

9. USA Today Circa 1997

12. Pharmanex ® = “Pharma-Next” “Next Generation Pharmaceutical”

13. I See a Future…

14. You as ambassadors of good health

15. I See a Future… You as ambassadors of good health The world knowing their antioxidant score

16. Extraordinary Science… Personalized Revolutionized Simplified

17. Extraordinary Science… Personalized Revolutionized Simplified

18. Body Fat and Antioxidant Protection 29,236 25,612 20,835 16,603 10,000 15,000 20,000 25,000 30,000 35,000 < 2525-2930-39> 40 Body Mass Index Antioxidant Score

19. Breaking News: Landmark Scanner Study Skin Carotenoid Score = Antioxidant Protection

20. Extraordinary Science… Personalized Revolutionized Simplified

21. Lighter – Smaller – Faster S1S2 Warm up time30 min5 min Calibration time17 min4 min Calibration steps9 scans3 scans Weight of scanner10 lbs~5 lbs Scan time3 min~2 min Temperature range 70 – 75 °F 21 – 24 °C 50 – 95 °F 10 – 35 °C

23. Global Rollout China, Europe, US Markets –February 2006 Other markets soon after! Learn more in your regional meeting

24. I See a Future… A Winning Strategy

25. I See a Future… A Winning Strategy Simplicity

26. Extraordinary Science… Personalized Revolutionized Simplified

27. Now is the time to Scan the World! 10 Million People by 2007

28. Michael’s Business Take-aways Original Pharmanex Slogan: “Pharmaceutical companies improve health with medicines, Pharmanex improves health without medicine” Pharmanex is derived from “Pharma-next” or “Next Generation Pharmaceutical”

29. Joe’s Business Take-aways 10M by 2007 The scanner is the gold standard for overall antioxidant protection We must “SCAN THE WORLD”

30. Major Accomplishments Global Product Rollout –BioPhotonic Scanner –TRA –Marine Omega –Estera Stevie Award; NBJ Award Product Certifications China Manufacturing Scanner “Oxidative Stress” Study

32. Mark R. Bartlett Ph.D. Sr. Director Pharmanex New Product Development Science & Tradition

33. Fruit Phytonutrients At least 1,000 phytochemicals identified with cell protective effects Very few (25) studied Fruits and vegetables – more than meets the eye We don’t eat enough fruits and vegetables

34. –R&D evaluated hundreds of fruits for … Extraordinary antioxidant power (Scanner) Extraordinary nutritional contents Quality of scientific efficacy data Impeccable safety data History of traditional folklore usage 3 years ago… Pharmanex began Searching the World for Superfruits

35. Why the long search and Why the long list?

36. Free Radicals Sources Environmental pollution (smog, ozone, NO 2 ) Radiation exposure: –sunlight (UV-light), X-rays, etc. Smoking: –10,000,000,000,000,000 free radicals/cigarette! Eating and Breathing: metabolism in your mitochondria

37. Mitochondria – The Energy Furnaces of the body Free Radicals SOD CAT

38. 1.Provo R&D Center 2.Shanghai R&D Center 3.Beijing R&D Center Pharmanex Research Centers were involved…

39. –Almost all failed Selection criteria –All but Four (g+3) very special fruits years of searching

40. Indigenous to Southern Asia Bangladesh, Burma, Cambodia, China, India, Japan, Laos, Malaysia, Philippines, Thailand, and Vietnam Traditionally used internally and externally Topical: wound healing Internally: eye health, and to promote growth in children Gâc - “ Fruit From Heaven ”

41. Antioxidants in Gâc Pulp Extraordinarily rich in antioxidants, esp. lycopene, beta-carotene, vitamin E Unique fatty acids → Lipocarotenes™ Fruit flesh (mesocarp) Pulp (aril) Seeds

42. 1.Gâc fruit (Chinese Bitter Cucumber) 2.Chinese Lycium (Wolfberry) 3.Cili fruit 4.Siberian Pineapple (Seabuckthorn) Pharmanex Research Centers 3 Years of Searching and R&D 3 +1 Superfruits

43. Gac Fruit Lycopene Content mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004 70 x more than tomatoes!

44. Gac Fruit Beta-Carotene Content mcg/g wet weight Ishida et al., J Agric Food Chem 52:274, 2004 10 x more than carrots!

45. Gâc Fights Vitamin A Deficiency …a Leading cause of blindness in the world…a Leading cause of blindness in the world In So. Asia, Gâc discovered as potent indigenous source of highly bioactive provitamin A (  -carotene)In So. Asia, Gâc discovered as potent indigenous source of highly bioactive provitamin A (  -carotene) 10 years of research by Dr. Le Vuong, Univ. of California, Davis, Nutrition Department10 years of research by Dr. Le Vuong, Univ. of California, Davis, Nutrition Department *Vuong LT et al., Am J Clin Nutr 2002;75:872-879.

46. Zeaxanthin in Chinese Lycium Fruit 40 x more than yellow corn! mcg/g wet weight

47. Vitamin C in Cili Fruit 60 x more than oranges! mg/100g wet weight

48. Lipocarotenes ™ Nature ’ s unique nutrient delivery system in Gâc –contain fatty acids (unique among fruits) –with carotenoids & vitamin E pre-dissolved –Gâc carotenes: 40 % improved uptake* *compared to beta-carotene powder. Vuong LT et al., Am J Clin Nutr 2002;75:872-879.

49. Vulnerable to Oxidation Vitamin C Lutein Lycopene Betacarotene

50. SOD CAT SOD Catalase Internal Antioxidants

51. Patent pending, 100%-juice formula First juice with Gâc worldwide Pharmanex bought world supply of Gâc & Cili (2004/2005 season) Proprietary

52. will increase your scanner score! –4,000 – 7,000 units @ 4 fl oz / day (8 weeks) –12,000 – 20,000 units with LifePak ® Use to take LifePak ® !

53. EFFECT OF AND OTHER JUICES ON ANTIOXIDANT STATUS AS MEASURED BY THE BIOPHOTONIC SCANNER

54. Purpose: To compare the effects of, XanGo ™ and Tahitian Noni ® juices on antioxidant status

55. Study Design Subjects (N=34) were randomly assigned to 1 of 3 groups Subjects consumed 3 fluid oz twice per day, with breakfast and with dinner for 8 weeks Comparable Daily Intakes –6 fl oz (Maximum recommended intake) –6 fl oz Tahitian Noni® (6x’s Recommended dose) –6 fl oz XanGo ™ (2x’s Recommended dose)

56. Increased Antioxidant Network Scores ~9,500 in 8 Weeks

57. Lipocarotenes ™ in are More Bioavailable 0 2,000 4,000 6,000 8,000 10,000 Other Carotenes g3 Lipo- carotenes Antioxidant Score

58. Increased Antioxidant Scores 4x ’ s More than XanGo ™ or Noni *p<0.05 compared to wk 0 #p<0.05 compared to other juices #, * * 0 2,000 4,000 6,000 8,000 10,000 Week 0Week 2Week 4Week 6Week 8 Antioxidant Score NoniXanGo ™ g3g3

59. Conclusions † : dramatically increases antioxidant scores. Lipocarotenes ™ in g 3 are 55% more easily absorbed. has 4x’s the antioxidant potential of either XanGo ™ or Tahitian Noni ® Juice. †Preliminary, unpublished data.

60. Angela Mastaloudis, Ph.D. Associate Senior Scientist Thanks to

61. Mark’s Business Take-aways Scanner Developed: was developed because of the scanner SCS Certified: Guaranteed to Increase Antioxidant Score Superfruit: A fruit that contains unusually high amounts of antioxidants Lipocarotenes™: Natures unique delivery system First to Market: Proprietary, Patent Pending, 100% Juice, World supply of Gâc and Cili Tahitian Noni® & XanGo ™ Lose: Noni and XanGo ™ lose to g3 in scanner study

62. The Power of Nanotechnology Carsten R. Smidt, Ph.D., FACN Vice President, Global R&D

63. What is Nanotechnology? Nanotube Wires Nano-Switch Example: Nano-Electronics

64. A Matter of Size 6000 nanometers Red Blood Cell 100 nanometers

65. What is Nanotechnology? 1.A Matter of Size: 1 -100 nanometers –Most molecules are 1 to 100 nm in size 2.Function at the Molecular Level –Nanotechnology is the science of manipulating substances at the molecular level

66. Pharmanex Nanotechnology To increase intestinal uptake of poorly absorbed fat-soluble nutrients: –Carotenoids (lycopene, alpha+beta- carotenes, zeaxanthin, astaxanthin) –Coenzyme Q 10

67. Reasons for Poor Absorption Poor intestinal solubility Requires fat for dissolution (e.g., Lipocarotenes) Aggregation into large particles –not easily digested and absorbed

68. The Nanotechnology Difference Small nano-particles are easily dispersed and absorbed

69. NanoCoQ10 ™

70. What is CoQ 10 ? Coenzyme Q 10, CoQ 10, or ubiquinone –fat-soluble, vitamin-like nutrient that catalyzes energy production in cells* –found in all cell membranes, nuclei and mitochondria –produced in the body — decreasing with age *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

71. CoQ 10 Health Benefits* Helps produce cellular energy, ATP Provides powerful protection against free radical damage inside the cell (mitochondria) Strengthens heart muscle - supports circulation Maintains existing normal blood pressure Skin health (anti-aging benefits) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

72. Regular CoQ 10 Products Not easily absorbed into the body High dose needed to achieve meaningful benefits NanoCoQ10 ™ uses molecular nano- encapsulation to significantly improve absorption

73. 5-fold increase in absorption!* 30 mg ≈ 150 mg *Preliminary, laboratory data CoQ10 Absorption by Human Intestinal Cells 0.0 50.0 100.0 150.0 200.0 250.0 300.0 Chewable AChewable BChewable CCoQ10 powder Nano-CoQ10 powder pmol/mg protein

74. Summary Breakthrough nanotechnology Highly bioavailable CoQ 10 Heart protection* Helps produce cellular energy* Antioxidant protection* Use with Celltrex ® CoQ10 Complete CoQ10 PowerPack More at the Nu Skin workshop! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

75. Introducing

76. Nano- Nutrients Nano-CoQ 10 Red Wine Polyphenols New Vitamin E Highly Effective Minerals

77. lifepak® nano: Nano-Antioxidants Nano-CoQ 10 Nano-Carotenoids?

78. lifepak®nano: Nano-Antioxidants New, broader-spectrum nano- carotenoid formula: –alpha-carotene –beta-carotene –lycopene –lutein –zeaxanthin (new): Eye health benefits* –astaxanthin (new): Immune response* plus LipoNutrients (proprietary process) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

79. lifepak®nano: Omega-3 Lipids Delivers MarineOmega benefits: –600 mg EPA, 400 mg DHA –Antarctic Krill oil Helps normalize omega 6/3 ratio in diet: –helps maintain normal inflammatory response* –promotes cardiovascular health* –supports brain & nervous system* *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

80. lifepak®nano: Vitamin E Formula Gamma-tocopherol: –synergistic antioxidant effects with alpha-tocopherol (neutralizes different free radicals)* –helps maintain normal inflammatory response* New vitamin E formula in lifepak® nano: –200 IU alpha-tocopherol (134 mg) –75 mg gamma-tocopherol –26 mg beta- and delta-tocopherols = 235 mg total vitamin E (201 mg in LifePak® Prime) *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

81. lifepak® nano: Mineral Sources 600 mg Calcium, with new patented dicalcium malate (soluble, organic Ca) 300 mg Magnesium, 100% amino acid chelate Plus 6 other bone nutrients: D, K, P, B, Si, resveratrol* Advantage: More efficient absorption and better GI tolerance than Ca and Mg in LifePak® Prime or LifePak® Women *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

82. lifepak® nano: Red Wine Actives “1-2 glasses of red wine a day keep the doctor away” (French Paradox) Cardiovascular benefits attributed to red wine polyphenols:* –Resveratrol –Proanthocyanidins –Quercetin lifepak ® nano = 2 glasses red wine a day! *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

83. New Packet Design Unique 2-chamber design –Separates soft-gels from hard shell capsules for optimum stability –New film with stronger protection and oxygen barrier (as in LifePak® Japan) Vitamins Minerals Phytonutrients proprietary CR-6 LipoNutrients

84. New Health Benefits* Helps maintain a healthy balance of pro- and anti- inflammatory signals (prostaglandins) in the body –Cardiovascular health (designed to lower C-reactive protein) –Joint health and mobility Expanded cell rejuvenation & anti-aging benefits –CR6-LipoNutrients™, red wine benefits, 60+ antioxidants, incl. nano-antioxidants Complete bone support (8 nutrients) New eye health benefits (lutein & zeaxanthin) Improved gastro-intestinal tolerance plus the benefits of LifePak® Prime *Theses statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

85. lifepak ® nano Study –57 subjects –20 week study 60+ Antioxidants Ongoing placebo-controlled clinical study LifePak Placebo lifepak nano –Better antioxidant response than LifePak®!

86. Nano- Nutrients Nano-CoQ 10 Red Wine Polyphenols New Vitamin E Highly Effective Minerals

87. For All Adults (age 18-121)

88. Cutting-Edge Science!

89. Broadest Health Benefits!

90. The New Dimension!

91. The Power of Nanotechnology Visit our PRODUCT SHOWCASE! Win an iPod nano with lifepak® nano! Purchase CoQ10 PowerPack and g3™!

93. Carsten’s Business Take-aways Nano Technology means increased absorption CR6-LipoNutrients ™ Technology is proprietary and patent-pending Gentle to the stomach Guaranteed to increase antioxidant score Do You NANO?

94. Now is the Time “The FUTURE is literally in your hands and in the hands of the people you scan” Joe Chang

95. Be a Champion 2005 Workshop