1. Jacqueline Castagno, MD FACOG Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of Florida College of Medicine

2. What is Human papillomavirus? HPV is a group of more than 150 related viruses. Some types cause warts while others may cause cancer and precancerous lesions. 40 types of the virus can be spread by some type of sexual contact

3. What diseases can HPV cause in women? HPV can cause: Genital warts Cervical cancer Cancer of the vagina Anal cancer Cancer of the vulva Lower genital tract dysplasia There are about 14 million new genital HPV infections in the United States yearly

4. Cervical cancer in the US - 2015 12,109 cases 4092 deaths Florida New cases estimated in 2015 Cervical cancer 980 Uterine cancer 3550 Breast cancer 15,470

5. Cervical cancer Most invasive cervical cancer is found in women who have not had a Pap smear in the past 5 years or have never been screened Most cervical cancers occur below age 50 Most cervical cancer treatment will result in loss of fertility, either hysterectomy or from radiation. Cervical cancer is once of the most common cancers in pregnancy Long term treatment complications can be severe for survivors

6. It is estimated that at the present time, over 249,000 women in the US are living with cervical cancer

7. Cervical cancer: Prevention Cervical cancer is a sexually transmitted disease Essentially all cervical cancers are caused by persistent HPV infections HPV types 16 and 18 cause 70-80% of cervical cancers Half of cases of squamous cell cervical cancer in the US are caused by HPV 16 HPV vaccines prevent nearly 100% of cervical and anal precancerous (dysplastic) lesions caused by HPV 16/18

8. We can prevent most HPV infections, and the diseases they cause, with the HPV vaccines

9. HPV vaccine is highly effective in preventing infections by the most common and most dangerous HPV types, however not all HPV types are covered. About 30% of cervical cancers will not be prevented by current vaccines HPV vaccines do not protect against other STDs Vaccinated women should continue cervical screening The vaccines do not treat cervical cancer or HPV infections

10. With widespread vaccination and continued screening, the next generation may never have to worry about cervical cancer.

11. To help prevent the spread of HPV, get vaccinated and tell your friends and the people you love about the vaccine. Let’s eliminate cervical cancer for the next generation