2. LIVER& GALLBLADDER
Dr Iram Tassaduq

3. Major salivary glands
Gallbladder
Pancreas
Liver

4. LIVER

5. LIVER
Largest mass of glandular tissue
Largest internal organ
1500 g in weight

6. ANATOMY OF LIVER

8. STRUCTURAL ORGANIZATION
Parenchyma
Connective tissue stroma
Sinusoidal capillaries (sinusoids)
Perisinusoidal space (space of Disse)

9. CAPSULE
The liver is enclosed in a capsule of fibromuscular connective tissue known as Gilson's capsule.
Thin capsule

10. LIVER CAPSULE

11. LIVER LOBULES
Classic Lobule
Portal Lobule
Liver acinus

12. CLASSICAL LOBULE

14. CLASSICAL LOBULE

15. PORTAL TRIAD
Hepatic artery
Portal vein
Bile duct

17. Portal lobule Emphasizes exocrine function
Includes those portions of three classical lobules that secrete bile that drains unto bile duct

19. LIVER ACINUS

20. LIVER ACINUS

22. BLOOD VESSELS OF PARENCHYMA

23. DIRECTION OF FLOW OF SUBSTANCES

24. HEPATIC SINUSOIDS

25. BLOOD SUPPLY

26. HEPATIC SINUSOIDS

28. KUPFFER CELLS

30. SPACE OF DISSE

32. STELLATE CELLS

33. STELLATE CELLS

34. SECRETION OF BILE

37. FORMATION OF LYMPH IN THE LIVER
Due to the large pores or fenestrations in sinusoidal endothelial cells, fluid and proteins in blood flow freely into the space between the endothelium and hepatocytes (the "space of Disse"), forming lymph. Lymph flows through the space of Disse to collect in small lymphatic capillaries associated with portal triads.

44. HEPATOCYTE

46. GALL BLADDER

48. MUCOSA

49. SPECIAL FEATURES OF MUCOSA
Microvilli
Junctional complexes
Concentration of mitochondria
Lateral plications

50. ROKITANSKY-ASCHOFF SINUSES

51. ABSENCE OF MUSCULARIS MUCOSAE AND SUBMUCOSA

52. MUSCULARIS EXTERNA

53. THANKYOU