1. DNA: Structure and Replication
CHAPTER 7
DNA: Structure and Replication
Copyright 2008 © W H Freeman and Company

2. CHAPTER OUTLINE 7.1 DNA: the genetic material 7.2 The DNA structure
7.3 Semiconservative replication
7.4 Overview of DNA replication
7.5 The replisome: a remarkable replication machine
7.6 Replication in eukaryotic organisms
7.7 Telomeres and telomerase: replication termination

3. Computer model of DNA
Chapter 7 Opener

4. A sculpture of DNA
Figure 7-1

5. DNA: the genetic material

6. Transforming R cells into S cells
Figure 7-2

7. DNA is the transforming agent
Figure 7-3

8. The phage genetic material is DNA
Figure 7-4

9. The DNA structure

10. Structures of the four DNA nucleotides
Figure 7-5

11. Table 7-1

12. Rosalind Franklin’s critical experimental result
Figure 7-6a

13. Rosalind Franklin’s critical experimental result
Figure 7-6b

14. The first model of DNA
Figure 7-7

15. The structure of DNA
Figure 7-8

16. Two representations of the DNA double helix
Figure 7-9

17. Base pairing in DNA
Figure 7-10

18. Semiconservative replication

19. Semiconservative DNA replication
Figure 7-11

20. Three alternative models for DNA replication
Figure 7-12

21. DNA is copied by semiconservative replication
Figure 7-13a

22. DNA is copied by semiconservative replication
Figure 7-13b

23. DNA is copied by semiconservative replication
Figure 7-13c

24. A replicating bacterial chromosome
Figure 7-14

25. A replicating bacterial chromosome
Figure 7-14a

26. A replicating bacterial chromosome
Figure 7-14b

27. Reaction catalyzed by DNA polymerase
Figure 7-15

28. Overview of DNA replication

29. DNA replication at the growing fork
Figure 7-16

30. Synthesizing the lagging strand
Figure 7-17

31. Unnumbered figure pg 281

32. The replisome: a remarkable replication machine

33. Proteins at work at the replication fork
Figure 7-18

34. DNA gyrase removes extra twists
Figure 7-19a

35. DNA gyrase removes extra twists
Figure 7-19b

36. Prokaryotic initiation of replication
Figure 7-20

37. Replication in eukaryotic organisms

38. Assembling nucleosomes during DNA replication
Figure 7-21

39. DNA replication proceeds in two directions
Figure 7-22

40. DNA replication proceeds in two directions
Figure 7-22a

41. DNA replication proceeds in two directions
Figure 7-22b

42. Stages of the cell cycle
Figure 7-23

43. Eukaryotic initiation of replication
Figure 7-24

44. Telomeres and telomerase: replication termination

45. The replication problem at chromosome ends
Figure 7-25

46. Telomere lengthening
Figure 7-26a

47. Telomere lengthening
Figure 7-26b

48. The telomeric cap structure
Figure 7-27