1. ACYLATION L.O.: What is an acylation reaction?
What is the nucleophilic addition-elimination mechanism fro acylation reactions?
worksheet

2. The acyl group:
Acylation is the process by which the acyl group is introduced into another molecule.

3. Think of examples of types of compounds containing the acyl group.

4. Explain page 78, 79

6. water + propanoyl chloride

7. ammonia + ethanoyl chloride 

8. propan-2-ol + ethanoyl chloride 

9. ethylamine + propanoic anhydride 

10. propylamine + butanoyl chloride 

11. propan-1-ol + ethanoic anhydride 

12. water + butanoic anhydride 

13. ammonia + propanoic anhydride 

14. Addition-elimination mechanism
Why is it called addition-elimination?

15. Addition-elimination mechanism

16. Name and outline the mechanism for the reaction between propanoyl chloride and methylamine.
Exam question (3a, page 83)

18. Advantages of using ethanoic anhydride over ethanoyl chloride as an acylating agent: Cheaper Less corrosive It does not react with water as readily Safer. By-product is ethanoic acid rather than HCl.

19. ASPIRIN