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Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee.

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Presentation on theme: "Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee."— Presentation transcript:

1 Influenza Vaccine Responses Roland A. Levandowski, M.D. Division of Viral Products Prepared for Vaccines and Related Biological Products Advisory Committee 18-19 February 2004

2 1. ALAN HAMPSONADULTA/NEW CALEDONIA/20/99-LIKE (H1N1) WHO, AUSTRALIAELDERA/PANAMA/2007/99 (H3N2) B/SHANGDONG/07/97 2. JOHN WOOD, PH.DADULTA/NEW CALEDONIA/20/99 (H1N1) NIBSC, ENGLANDELDERA/PANAMA/2007/99 (H3N2) B/SHANGDONG/7/97 3. TAKATO ODIGARI, PH.D. ADULTA/NEW CALEDONIA/20/99-LIKE (H1N1) WHO, JAPANELDERA/PANAMA/2007/99-LIKE (H3N2) B/HONG KONG/330/01-LIKE Serum Panels for Serologies

3 4. STEFAN GRAVENSTEIN, M.D.ADULTA/NEW CALEDONIA/20/99 (H1N1) EASTERN VIRGINIA ELDERA/PANAMA/2007/99 (H3N2) MEDICAL SCHOOLCHILDB/HONG KONG/1434/2002 5.CHRISTINE TURLEY, M.D.CHILDA/NEW CALEDONIA/20/99 (H1N1) UTMB A/PANAMA/2007/99 (H3N2) GALVESTON, TEXASB/HONG KONG/1434/2002 6.STEFAN GRAVENSTEIN, M.D.ADULTB/VICTORIA/504/2000 ELDER (VACCINE USED IN 2001-02) 7.JOHN WOOD, PH.D ADULTB/JOHANNESBURG/5/99 (VACCINE USED IN 2001-02)

4 ANTIGENS FOR SEROLOGIES (H1) VACCINE STRAIN A/NEW CALEDONIA/20/99 (H1N1) REPRESENTATIVE CURRENT STRAINS A/DAKAR/85/2003 (H1N1) A/MINNESOTA/18/2003 (H1N1) A/NAGANO/1328/2003 (H1N1) A/BELEM/84066/03 (H1N2) A/ICELAND/123/2003 (H1N2) A/PERU/2223/2003 (H1N2) A/VIRGINIA/20/03 (H1N2)

5 HI ANTIBODY RESPONSES TO THE H1 COMPONENT 2003-2004 INFLUENZA VACCINE ADULT POPULATION (CDC)

6 HI ANTIBODY RESPONSES TO THE H1 COMPONENT 2003-2004 INFLUENZA VACCINE ELDERLY POPULATION (NIBSC)

7 HI ANTIBODY RESPONSES TO THE H1 COMPONENT 2003-2004 INFLUENZA VACCINE PEDIATRIC POPULATION (CDC AND CBER)

8 A/NEW CALEDONIA/20/99-LIKE VACCINES SUMMARY TABLE VIRUSES WITH > 50% GMT REDUCTION

9 ANTIGENS FOR SEROLOGIES (H3) VACCINE STRAIN A/PANAMA/2007/99 REPRESENTATIVE CURRENT STRAINS A/CHILE/82660/2003 A/AICHI/205/2003* A/KUMAMOTO/102/2002* A/FUJIAN/445/2003* A/NAGASAKI/152/2003** = FUJIAN/411-LIKE A/TEXAS/40/2003* A/TEXAS/141/2003* A/WYOMING/03/2003* A/HONG KONG/1186/2002*

10 HI ANTIBODY RESPONSES TO THE H3 COMPONENT 2003-2004 INFLUENZA VACCINE ADULT POPULATION ( AUS )

11 HI ANTIBODY RESPONSES TO THE H3 COMPONENT 2003-2004 INFLUENZA VACCINE ELDERLY POPULATION (CDC)

12 HI ANTIBODY RESPONSES TO THE H3 COMPONENT 2003-2004 INFLUENZA VACCINE PEDIATRIC POPULATION (CDC AND CBER)

13 A/PANAMA/2007/99-LIKE VACCINES SUMMARY TABLE VIRUSES WITH > 50% GMT REDUCTION

14 ANTIGENS FOR SEROLOGIES (B) VACCINE STRAIN CURRENT VACCINE OLDER VACCINE B/SHANGDONG/7/97+ B/JOHANNESBURG/5/99 B/HONG KONG/1434/2002+ B/VICTORIA/504/2000 REPRESENTATIVE CURRENT STRAINS B/SICHUAN/259/2003+ B/BADEN-WURTENBURG/26/2002* B/SHAHGHAI/361/2002* B/JIANGSU/10/2003*+ = HONG KONG/330-LIKE B/JILIN/20/2003** = SHANGHAI/361-LIKE B/MALAYSIA/879/2003* B/WASHINGTON/3/2003*

15 HI ANTIBODY RESPONSES TO THE B COMPONENT 2003-2004 INFLUENZA VACCINE ADULT POPULATION (NIBSC)

16 HI ANTIBODY RESPONSES TO THE B COMPONENT 2003-2004 INFLUENZA VACCINE ELDERLY POPULATION (CDC)

17 HI ANTIBODY RESPONSES TO THE B COMPONENT 2003-2004 INFLUENZA VACCINE PEDIATRIC POPULATION (CDC AND CBER)

18 HI ANTIBODY RESPONSES TO THE B COMPONENT 2001-2002 INFLUENZA VACCINE ADULT AND ELDERLY (NIBSC AND CBER)

19 B/HONG KONG/330/2001-LIKE VACCINES SUMMARY TABLE VIRUSES WITH > 50% GMT REDUCTION

20 Influenza Vaccine Responses Summary Studies with sera collected after immunization with current vaccines show that: Representative influenza A (H1N1) and (H1N2) viruses are well-inhibited Many a/Fujian/411/2002 (H3N2)-like viruses are less well inhibited than the the vaccine strain B/Hong Kong/330/2001-like viruses are well inhibited but B/Shanghai/361/2002 and similar viruses are less well inhibited than the vaccine strains

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