1. LETTURA A TEMA Fibrillazione Atriale: Stato dell’Arte Prof. Luigi Padeletti Presenta: Saverio Iacopino Sant ’ Anna Hospital Catanzaro

4. Network for person: Padeletti, Luigi

6. HF and AF are “ emerging epidemics ”

7. The interaction between AF and HF means that neither can be treated optimally without treating both HF AF promotes aggravates

8. Ventricular resynchronization and atrial pacing (algorithms, atrial resynchronization) may be considered a major revolution in treating AF and HF by electrical stimulation

9. Primary outcome: device-classified AT/AF frequency Secondary outcomes: device-classified AT/AF burden and PAC frequency Padeletti et al. JCE. 2003

10. Long-term Reduction of AT Recurrences in Patients Paced for BT-SND In a long-term observation on BT-SND patients, a significant decrease of AT related hospitalizations and increase of mean AT cycle length were measured. These data suggest that rhythm control therapies may induce an inversion of AT progression. Padeletti et al. HR. 2005

11. MASCOT Trial Multicenter, single-blind, randomized, parallel study evaluating the safety and efficacy of a specific AOP algorithm (AF Suppression™, St Jude Medical, Sylmar, CA) in CRT patients. After successful CRT device implantation, and before hospital discharge, the patients were randomly assigned to AOP ON versus OFF for the duration of follow-up. Padeletti et al. AHJ. 2008

12. MASCOT Trial: Incidence of Permanent AF

13. Padeletti et al. AHJ. 2008 MASCOT Trial: Mortality

14. The two options to treat AF are either rhythm control defined as the strategy to restore and maintain sinus rhythm or rate control defined as the strategy to maintain the patient in AF and avoid too fast and too slow ventricular rates….. Padeletti L. et al. EHJ 2007