1. The Structure and Function of Blood

2. Composition of Blood Blood is responsible for….. – Transporting gases (oxygen & carbon dioxide) – Transporting waste products – Transporting nutrients – Helping remove toxins from the body

3. Composition of Blood Blood makes up 6–8% of our total body weight. Normal adult blood volume is 5 L. Blood is made up of cellular material in a fluid called plasma.

4. Composition of Blood Blood is a circulating tissue consisting of three types of cells. 1.Red Blood Cells  Erythrocytes 2.White Blood Cells  Leukocytes 3.Platelets  Thrombocytes The cells listed above are suspended in a liquid known as plasma.

5. Composition of Blood: Red Blood Cells Red Blood Cells — AKA: Erythrocytes or RBCs — Most abundant cell in the blood (4 million – 6 million per microliter of blood) — Formed in the bone marrow —Main function is transporting oxygen and carbon dioxide http://www.g iantmicrobes. com/us/prod ucts/redblood cell.html

6. Composition of Blood: White Blood Cells White blood cells — AKA: Leukocytes or WBCs — Largest sized blood cells — Lowest numbers in the blood (4,500 – 11,000 per microliter) — Formed in the bone marrow and some in lymph glands — Primary cells of the immune system — Fights disease and foreign invaders http://w ww.gian tmicrob es.com/ us/prod ucts/whi tebloodc ell.html

7. Composition of Blood: Platelets Platelets — Involved in the clotting process — Seal wounds and prevent blood loss — Help repair damaged vessels — 150,000 – 400,000 per microliter of blood —Platelets stain bluish with reddish or purple granules

8. Formation of Blood Hematopoiesis  the formation and development of blood cells

9. Blood Evidence Blood spatter – Can be analyzed to determine patterns that give investigators clues to how a crime might have happened. Blood droplets – Can be analyzed to give clues to the location of a crime, movement of a victim, and type of weapon. Blood samples – Can be analyzed to determine blood type and DNA, which can be matched to possible suspects.

10. Microscopic Views Bird Blood Cat Blood Dog Blood Fish Blood Frog Blood Snake Blood Human Blood Horse Blood

11. Blood Typing Definitions Antibody- a protein that identifies foreign matter by shape and begins immune response Antigen- a foreign small molecule that the body can attack with an antibody Agglutination- clumping that occurs in blood when antibodies connect to antigens on different red blood cells forming a meshwork.

12. ABO blood types Possible blood types: A, B, AB, and O + or – for each 8 total possibilities One gene with three possible alleles controls ABO ABor O A separate gene determines +/-

13. ABO blood types http://learn.genetics.utah.edu/units/basics/blood/types.cfm Blood type describes the proteins called antigens on the surface of the red blood cells. The letter(s) in the blood type indicate(s) the antigens on the red blood cell

14. Antibodies and ABO blood types http://learn.genetics.utah.edu/units/basics/blood/types.cfm The body makes antibodies to all the antigens not on its own RBC.

15. Genetics of Blood Types Your blood type is established before you are BORN, by specific GENES inherited from your parents. You inherit one gene from your MOTHER and one from your FATHER. These genes determine your blood type by causing proteins called AGGLUTINOGENS to exist on the surface of all of your red blood cells.

16. Blood Transfusions Red Blood Cell Donation or Whole Blood Donation We transfuse in the red blood cells and antigens of the donor. Universal Donors: TYPE O blood has no antigens is not recognized as foreign Universal Recipients: TYPE AB blood has no antibodies does not recognize other blood as foreign Rh +  Can receive + or - Rh -  Can only receive - (plasma transfusion is different)

17. Rh Factors A+ A- B+ B- AB+ AB- O+ O- http://www.fi.edu/biosci/blood/rh.html If a person is Rh +/- or +/+ the RBC also have D antigen A person with a positive blood type can receive blood transfusion from positive or neg A person with a negative blood type can receive blood transfusion from neg only Rh antigens can cross the placental barrier. Pregnant women who are Rh Neg get a shot to prevent mounting an immune response to a fetus with Rh Pos