1. Suzanne Simon Cancer Center Administrator James Fitzpatrick Sr. Director of Scientific Core Facilities Director of the Advanced Biophotonics Core

2.  Founded by Jonas Salk in 1970  Designated as NCI Basic Center in 1973 ■ Center includes 30 Faculty members ■ 200 Post-doctoral researchers ■ 50 Graduate research students  Cancer Center Director: Tony Hunter, Ph.D.  Cancer Center is distributed across Salk ■ 62% of Institute participate in Center programs

3.  NCI Review of Center Renewal (2008) ■ Recommendation for central database Collect, administer and interrogate Shared Resource Use Provide uniform invoicing for all laboratories Provide ability to track CC vs non CC use  Challenges: ■ Most CC supported cores – legacy systems ■ Need existed to create a uniform system for all cores Collecting data Invoicing users Tracking usage

4.  13 Scientific Core Facilities at Salk Biophotonics and Imaging (BPHO) Animal Behavior Testing (BTC) Flow Cytometry (FCCF) Functional Genomics (FGL) Genome Manipulation (GMC) Gene Transfer, Targeting and Therapeutics (GT3) Integrative Genomics and Bioinformatics (IGC) Histology (HIC) Next-Gen Sequencing (NGS) Peptide Synthesis (PSC) Proteomics (MASS) Stem Cell (STEM) Transgenic Animals (TGC)

5.  13 Scientific Core Facilities at Salk Biophotonics and Imaging (BPHO) Animal Behavior Testing (BTC) Flow Cytometry (FCCF) Functional Genomics (FGL) Genome Manipulation (GMC) Gene Transfer, Targeting and Therapeutics (GT3) Integrative Genomics and Bioinformatics (IGC) Histology (HIC) Next-Gen Sequencing (NGS) Peptide Synthesis (PSC) Proteomics (MASS) Stem Cell (STEM) Transgenic Animals (TGC)

6.  13 Scientific Core Facilities at Salk Biophotonics and Imaging (BPHO) Animal Behavior Testing (BTC) Flow Cytometry (FCCF) Functional Genomics (FGL) Genome Manipulation (GMC) Gene Transfer, Targeting and Therapeutics (GT3) Integrative Genomics and Bioinformatics (IGC) Histology (HIC) Next-Gen Sequencing (NGS) Peptide Synthesis (PSC) Proteomics (MASS) Stem Cell (STEM) Transgenic Animals (TGC)

7.  13 Scientific Core Facilities at Salk Biophotonics and Imaging (BPHO) Animal Behavior Testing (BTC) Flow Cytometry (FCCF) Functional Genomics (FGL) Genome Manipulation (GMC) Gene Transfer, Targeting and Therapeutics (GT3) Integrative Genomics and Bioinformatics (IGC) Histology (HIC) Next-Gen Sequencing (NGS) Peptide Synthesis (PSC) Proteomics (MASS) Stem Cell (STEM) Transgenic Animals (TGC)

8.  13 Scientific Core Facilities at Salk Biophotonics and Imaging (BPHO) Animal Behavior Testing (BTC) Flow Cytometry (FCCF) Functional Genomics (FGL) Genome Manipulation (GMC) Gene Transfer, Targeting and Therapeutics (GT3) Integrative Genomics and Bioinformatics (IGC) Histology (HIC) Next-Gen Sequencing (NGS) Peptide Synthesis (PSC) Proteomics (MASS) Stem Cell (STEM) Transgenic Animals (TGC)

9.  Flexible system ■ Each core facility receives requests differently Scheduling time on microscopes or cytometers Requesting different DNA / protein sample preps ■ End result: need to accommodate different data inputs  System must interface with Banner (FIN)  Multiple user access ■ Core Managers, CC Admin / Director, Core Director  Reporting (CC data tables)

10.  Several Commercial Vendor Options ■ iLabs Solutions / CORES ■ PPMS ■ Idea Elan  Large upfront cost plus yearly charges  Built for larger enterprise solutions  CHALLENGE: ■ Lack of dedicated funds to purchase system ■ No dedicated full-time administrator to manager

11.  Given Salk’s small size – homegrown solution ■ Flexibility to custom-design interfaces for each core ■ Salk Business Info Systems to administer databases ■ Ability to directly interface with Salk Financial system  James Fitzpatrick (BPHO Dir / Sr. Dir CORES) ■ Worked with Suzy Simon (CC Admin) ■ Developed centralized invoicing and usage tracking ■ CRMS – Core Recharge Master System

12. FIN LABS Core Labs NCI NEI NINDS etc… Salk Databases Chart of Accounts Lab Table People Core DatabasesRecharge Master Pre-invoicing Cycle Reporting RACT Editing Data Warehouse

13. FileMaker Pro 12 BPHO FCCF FGL GT3 IGC MASS Input Methods WEB Scheduler PPMS WEB Internal Interface Direct User Input WEB External Interface BTC GMC HIC NGS PSC STEM TGC Core Manager Input

14. Core Databases Salk Databases CHART OF ACCOUNTS DEPT TABLE / PEOPLE CONTACTS Recharge Master Internal Fund Lab PI User Person Code Qty Product Description Charge Date of Charge Recharge Period NCI Rate Serial Recharge Center External PO IDC Rate Sales Tax MTA ORG BPHO FCCF FGL GT3 IGC MASS BTC GMC HIC NGS PSC STEM TGC On-line Soon IGC PSC BPHO BTC FCCF FGL GMC GT3 HIC IGC NGS PSC MASS STEM TGC BPHO BTC FCCF FGL GMC GT3 HIC IGC NGS PSC MASS STEM TGC RACT FIN FIN PO’s / Contacts EXTERNAL LABS FILER Internal Usage Reporting and Invoicing Years Labs/Depts Recharges Monthly PDF Reports

15.  CRMS system functional  Project start April 2013  Current Status (1 year later…) : ■ 11/13 cores recharging through this system ■ Remaining two will be in production by April 2014 ■ System fully functional by June 30, 2014  Provides reporting ■ Essential for grant progress reports and renewals ■ Provides usage information to both labs and Institute