1. Drug Formulation / Drug Delivery Raj Suryanarayanan (Sury) Department of Pharmaceutics College of Pharmacy surya001@umn.edu 1

2. Faculty Research Areas Biological Pharmaceutics (Pharmacokinetics, Pharmacodynamics, Metabolism) Elmquist, Fairbanks, Sawchuk, Zimmerman Physical Pharmaceutics (Materials Science) Suryanarayanan, Sun Drug Delivery Kandimalla, Prabha, Panyam, Siegel, Wiedmann 2

4. Center for Translational Drug Delivery Developing collaborative relationships with pharmaceutical companies in the area of drug delivery 4 Raj Suryanarayanan(Sury), Pharmaceutics Surya001@umn.edu

5. Goals and missions of the Center Bring together faculty with interest in drug delivery Leverage our comprehensive expertise in drug delivery – develop collaborations with pharmaceutical companies Work with the different administrative units to expedite legal and contractual issues Serve as a platform for training grants and program project grants that are focused on drug delivery 5

6. AeroCore Supporting research and product development through inhalation drug delivery

7. Core Activities Aerosol generation Characterization of aerosol particles (output/particle size distributions) Exposure of rodents to aerosol particles or vapors Measurement of chemicals deposited in the respiratory tract and accumulation in blood of rodents Gross and microscopic examinations of rodents Disease induction in animal models (e.g. cancer)

8. 1.Drug solubilization through engineering solid form (nanocaging, solid dispersion, cocrystallization, salt formation, etc.) 2.Tablet formulation and manufacturing process understanding and control 3.Structure-mechanical property relationship in organic crystals and powders The aqueous solubility of poorly soluble drugs is significantly improved by nanocaging. C.C. Sun

9. Kandimalla lab drug delivery projects  Design of nanotheranostics for the diagnosis and treatment of cerebrovascular diseases.  Elucidation of biophysical properties of endogenous macromolecules and their transport across the cellular barriers, particularly the blood brain barrier.  Development of novel drug delivery approaches to disrupt bacterial biofilms.  Strategies to evaluate and enhance oxidative stability of natural carrier oils.

10. Prabha Research Interests Oral formulations to improve bioavailability of poorly soluble drugs Anti-angiogenic therapy for ovarian cancer Photodynamic therapy for treating microbial infections in chronic wounds Sustained protein/gene delivery for chronic wounds

11. Panyam Research Interests Targeted Antibiotic Delivery for Chlamydial Infections NIAID/NIH Magnetic Hyperthermia for Lung Cancer Department of Defense Targeting Cancer Stem Cells Randy Shaver Foundation Polymeric Systems for Cancer Prevention/Treatment NCI/NIH

12. SIEGEL LAB Polymeric Drug Delivery Systems, Hydrogels Microfabricated Sensors (e.g. temperature, pH, glucose) Intranasal Delivery of Low Solubility, Fast Acting Drugs Unabsorbed DZP Cleared in Nasopharynx Diazepam (DZP) prodrug administered with converting enzyme Absorption Through Nasal Mucosa DZP in Bloodstream Crystallization in Nasal Cavity Starting LineFinish Line “Crystallization” Horse“Absorption” Horse Application: Canine Epilepsy