1. Influenza Vaccine Production and Immunization Update November 2007 MKT13556

2. sanofi pasteur is Unique in its Involvement in Every Facet of Influenza Vaccine Supply and Distribution Sanofi pasteur and its customers share common goals Raise immunization rates and improve access to vaccine Maintain consistent communication regarding influenza vaccine In pursuit of our common goals, sanofi pasteur: Closely coordinates with the Centers for Disease Control and Prevention (CDC) and other medical and public health authorities Manages all aspects of influenza vaccine order fulfillment Proactively seeks to provide broad access to all customer segments

3. MKT13556 sanofi pasteur’s Supply Plans for 2007-2008 Influenza Season and Beyond Current production plan is 50M doses Additional doses are contingent on production yields and demand throughout the full immunization season For example, in 2006 sanofi pasteur produced 54M doses Investing $150M in a new facility that will double capacity for influenza vaccine production 100M dose production capacity Planned increase for single-dose presentation This new facility is expected to come on-line for the 2008-2009 influenza season

4. MKT13556 A Record 120M Doses Were Supplied for the 2006-2007 Influenza Season Source: CDC, Greg Wallace, Vaccine Supply & Assurance Branch Mil. Doses

5. MKT13556 Vaccine Supply Expected to Increase Significantly in the Short-Term* (millions of doses) *Based on data presented at the 2/21/07 Advisory Committee on Immunization Practices meeting and sanofi pasteur estimates

6. MKT13556 Distribution Goals Designed to Address Each Season’s Unique Dynamics Provide broad access across all customer segments Increase immunization rates in line with the CDC’s Healthy People 2010 goals Reach all market segments as equitably as possible High-risk patients are served across multiple access points Support the CDC’s annual influenza recommendations Fully implement last year’s 6-59 month of age immunization recommendation Educate market on the revised ACIP recommendation* for 2 doses in naive or partially immunized patients 9 years of age and younger Prepare market for expected supply growth *ACIP released 2007-2008 recommendations later in 2007

7. MKT13556 Sanofi pasteur provides influenza vaccine across all customer segments Private Office-Based Providers Public Health ‡ Hospitals/ Long-Term Care Facilities/Institutions Retail Pharmacies CIP † /VNAA 2006-2007 Direct and Indirect Sales* (% of doses committed) Vaccines for Children Program State and Local Public Health Departments US Veterans Administration US Military ‡ Historically, Public Health administers approximately 22% of the overall influenza market supply * Source: sanofi pasteur internal estimates of 2006-2007 shipping results † Community Immunization Provider

8. MKT13556 Request Fulfillment Process – Shipping Shipping began as soon as vaccine was released by the FDA in August Virtually no inventory is stored during peak demand periods Shipping notifications are sent one to two weeks prior to shipment to inform customer of delivery window Typically occurs prior to final product release, which prevents the identification of an exact delivery date To identify an exact delivery date, inventory would need to be built which would only delay shipment

9. MKT13556 Request Fulfillment Process – Shipping Two to three partial shipments per customer are planned to ensure that we provide broad access to all customer segments throughout the entire immunization season Supported by the CDC as a “best demonstrated practice” More costly for sanofi pasteur, but supports the public need Full shipments would limit the number of customers receiving early season doses

10. Faces of Influenza: Consumer Awareness Campaign

11. MKT13556 Faces of Influenza - Agenda Situational analysis of upcoming influenza season What is the Faces of Influenza? 2006 program success Activities for 2007-2008 influenza season Benefits to the community

12. MKT13556 Situation for 2007-2008 Influenza Season Influenza immunization recommendations apply to 218M Americans Moving towards universal recommendations for 300M Americans US supply to surpass demand A record 120M doses supplied in 2006, however later than expected Between 130-170M doses may be available in the next few years Consumer awareness regarding the seriousness of Influenza and the safety of the vaccine is low It will be extremely challenging to immunize 130-170M people during the current 2-3 month immunization season Need to utilize the entire influenza season

13. MKT13556 Faces of Influenza Highlights What is Faces? Faces of Influenza is a consumer awareness campaign developed through a collaboration between the American Lung Association and sanofi pasteur Goal of the campaign: put a “face” on influenza illness and help Americans understand need for annual vaccination Help people personally identify with influenza See themselves and loved ones among Centers for Disease Control and Prevention (CDC) recommended groups for immunization Stress seriousness of influenza throughout full immunization season Stress the safety of influenza vaccine

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15. Faces of Influenza Highlights – 2006 Campaign Results: More than 550 million total media impressions Public service announcements ranked in top 12% of campaigns Six regional events in Phoenix, Detroit, Minneapolis/St. Paul, Philadelphia, Seattle, and Houston, secured significant media coverage for local Lung Associations: 36 million media impressions Activities in December and January fueled coverage of full season utilization

16. MKT13556 Faces of Influenza: 2007 Campaign Elements Comprehensive national campaign Six targeted regional campaigns Regional grassroots campaigns Local partnerships to promote influenza immunization Opportunity to reach more consumers with an important public health message in our local market

17. MKT13556 Faces of Influenza National Campaign Celebrity-driven consumer awareness campaign featuring Jennifer Garner Television and radio public service announcements National media event in New York City - November Updated program materials including website “Are you a Face of Influenza?” quiz Augmented media outreach vehicles Television and radio satellite media tour (SMT) Audio News Release (ANR) for radio Mat release - newspaper ready article Extensive media outreach to print and broadcast outlets, including morning shows and entertainment programs

18. MKT13556 Faces of Influenza Regional Events Conduct six celebrity-supported consumer awareness campaigns over a 4-6 week period in November and December 4-week media outreach blitz in each market Peaks with event in high traffic location Planned promotional activities include: Conduct media relations and controlled advertising to saturate market and drive influenza vaccination messages In addition to national celebrity, partner with local celebrity and physician Conduct media events at a high-traffic location in local market Post-event controlled promotion and media in each market Coalition will serve as an in-market resource to media Locations – Detroit, Houston, Minneapolis/St. Paul, Philadelphia, Phoenix, and Seattle

19. MKT13556 Mission: Provide a new platform to speak about influenza to consumers and health-care providers Proven, creative, and “media sexy” consumer campaign Increase immunization rates at the local level throughout the full immunization season Put a “face” on influenza illness and help your local audience understand need for annual vaccination Research conducted during the 2006-2007 campaign found immunization rates increased in regional markets using the campaign Provide consistent messages to the public Combat challenges faced in previous influenza seasons and education efforts Assist stakeholders and coalitions in their public health advocacy Faces of Influenza: Grassroots Regional Campaign

20. MKT13556 Faces of Influenza Grassroots Toolkit Table of Contents Building collaboration within our community Consumer education materials Media outreach materials

21. MKT13556 Faces of Influenza Grassroots Toolkit Building a collaboration within our communities: How-to guide for the toolkit and campaign in a binder Internet instructions for all materials, available via LungNet A Faces of Influenza presentation designed specifically for potential partners Timeline and key milestones for campaign

22. MKT13556 Faces of Influenza Grassroots Toolkit Consumer education materials: Faces of Influenza Portrait Book Faces of Influenza brochures Faces of influenza poster “Are you a Face of Influenza?” quiz Various fact sheets Template graphics and text to link to the Faces of Influenza Web site www.facesofinfluenza.org An influenza background presentation for partners to use Communication templates – newsletter article, Web article, patient and consumer letter, physician letter, elected official, heath official, school, office on aging Advertising Template – newspaper, Web, radio and TV scripts Influenza and immunization talking points and Q&A

23. MKT13556 Faces of Influenza Grassroots Toolkit Media outreach materials: Press release templates General awareness Clinic announcement Educational event announcement “Outbreak” alert Letter-to-the-editor and Op-Ed Various extend the season announcements Disease backgrounder for media outlets Influenza talking points and Q&A Copies of the TV and radio PSA for distribution to local media

24. MKT13556 Faces of Influenza: Grassroots Regional Campaign Working together we can successfully: Improve influenza immunization rates and reduce influenza mortality and illness Take a leadership role in the prevention of influenza within our communities Minimize the confusion of mixed messages Leverage the power of a high profile national consumer awareness campaign Magnify the power of the “one voice” concept

25. MKT13556 Faces of Influenza Regional Grassroots Campaign How do we move forward? Convene working group to determine how the campaign materials can be utilized by your group to increase consumer awareness Lung Association/sanofi pasteur to deliver resources to partners Lung Association/sanofi pasteur to work with your group to implement campaign APRMAYJULYAUGJUNEOCTSEPTNOVDECJAN

26. MKT13556 Next Steps Questions?

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