1. Breast Cancer Shannan McQuade & Ashley Haman

2. History of Breast Cancer Ancient Egyptians discovered Breast Cancer –Over 3,500 years ago Hippocrates discovered it Named the disease karkinos –Greek name for “crab”

3. History Cont. Henri Le Dran In 1957 suggested that surgical removal of the tumors could help treat it Infected lymph nodes of the armpit must be removed 1900 & 2000 William Halsted developed radical mastectomy that removed breast and auxiliary node

4. What happens? There are no known symptoms (early breast cancer) Later symptoms (women): –Lump on breast or near armpit Hard, uneven edges Usually doesn’t hurt –Change in size, shape, or feel of breast/nipple –Fluid from nipple Symptoms in men: –Breast lump –Breast pain and tenderness Advanced Symptoms: –Bone pain –Breast pain –Skin ulcers –Swelling of armpit by breast –Weight loss

5. Treatment Factors Discovery: –Breast MRI –Breast ultrasound –Breast biopsy –CT scan –Mammography –PET Scan Type and stage Sensitive to hormones Over produces HER2/neu –Transmembrane protein

6. Treatment Local –Only area of disease Radiation and surgery Systemic –Affects whole body chemotherapy Lumpectomy (remove lump) Mastectomy (removes all of breast) Targeted therapy (Biologic therapy) –Anti-cancer drug target certain cell Hormone therapy –Block hormones that fuel cancer growth Drug tamoxifen Aromatize inhibitors Chemotherapy Radiation therapy

7. How is Breast Cancer passed on? Only 10% of Breast Cancer is inherited. –Caused by mutated gene –The gene is usually passed down from mother (sometimes father) Only know of two genes that cause breast cancer: –BRCA 1 & BRCA 2 Other causes include: –Late pregnancy –Age: ¼ affect women under 50 ½ affect women between the ages of 50-69 ¼ affect women 70 years or older

9. Interesting Facts Kathy Bates Sheryl Crow Ann Romney Richard Roundtree Judy Bloom 1/8 women will have breast cancer 226,000 women in the US will be diagnosed this year 2,200 men in the US will be diagnosed

10. Works Cited American Institute for Cancer Research. American Institute for Cancer Research. 12 Feb. 2013. Web. 25 Feb. 2013. Mandal, Ananya Dr. MD. “History of Breast Cancer.” News Medical. n.p. Web. 25 Feb. 2013. Donnelly, Kaitlin. “17 Celbs Who Lived with Breast Cancer.” Prevention. Prevention. Sep. 2012. Web. 25 Feb. 2013. Pub Med Health. U.S. National Library of Medicine. 18 Sep. 2012. Web. 25 Feb. 2013.