2.  Definition of Chemotherapeutic Drug Administration  Administration of Chemotherapeutic Agents  Dosage of chemotherapeutic administration  Equipment of chemotherapeutic drug administration  Implementation of administration chemotherapeutic drugs.

3.  Administration of chemotherapeutic drugs requires skills in additional to those used when giving other drugs.  For example some drugs require special equipment or must be given through unusual route.

4.  Others drugs need protection from the light  specially trained nurses and physicians should give chemotherapeutic drugs.

5.  Chemotherapeutic agents may be administered in the hospital, clinic, or home setting by topical, oral, intravenous, intramuscular, subcutaneous, arterial, intracavitary.  The administration route usually depends on the type of agent, the required dose, and the type, location, and extent of tumor being treated.

6.  Dosage of antineoplastic agents is based primarily on the › patient’s total body surface area › previous response to chemotherapy or radiation therapy › major organ function.

7.  Nausea and vomiting  Intestinal irritation  Stomatitis  Hearing loss  Anemia  Alopecia

8.  Diarhea  constipation  Inflammation, ulceration, necrosis and loss of vein patency.

9.  1-Prescribed drug  2-Gloves  3-Aluminum foil  4-Normal saline solution  5-Syringe and needles  6-Normal pump or controller

10.  Assess the patient's physical condition, and review his medical history  Make sure you understand what chemotherapeutic agent needs to be given and by what route, and provide the necessary teaching and support to the patient and his family

11.  Confirm the patient's identity according to your facility policy  Determine the best site to administer the drug, When selecting the site, consider drug compatibilities, frequency of administration

12.  Evaluate your patient's condition, the result of recent laboratory studies.  Determine whether the patient has received chemotherapy before,and note the severity of any adverse effects.  Check his drug history for medications that may interfere with chemotherapy. Talk with the physician or pharmacist before you give it.

13.  Check the patient's chart for complete chemotherapy protocol order, including the patient's name and dosage, and route,rate and frequency of administration  Check to see whether the physician has ordered an antiemetic, fluids, a diuretic, or electrolyte supplements to be given before, during, or after chemotherapy administration.

14.  Evaluate the patient's and his family's understanding of chemotherapy, and make sure the patient or a responsible family member has signed the consent form.  Put on gloves. Keep them on through all stages of handling the drug including preparation, I.V. tubing, and administration.

15.  Before administering the drug avoid giving chemotherapeutic drugs through an existing I.V. line.  To identify an administration site, examine the patient's veins starting with his hands and proceeding to his forearm.  When an appropriate line is in place, infuse 10 to 20 ml of normal saline solution to test vein patency.

16.  Never test vein patency with a chemotherapeutic drug. Next, administer the drug as appropriate.  Closely monitor the patient for signs of hypersensitivity reaction.  After infusion of the medication, infuse 20 ml of normal saline solution. Do this between administrations of different chemotherapeutic drugs and before discontinuing the I.V. line.

17.  Dispose of used equipment in properly container.  Wash your hands thoroughly with soap and warm water after giving any chemotherapeutic drug

18.  Location & description of the I.V site before treatment  Record the drug & dosage administration  Sequence of drug administration  Needle type and the size used  Amount & type of flushing solution

19.  Document any adverse reaction  Patient’s tolerance of treatment.  Topics discussed with the patient and his family.