1. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Passing on genetic information from parents to children An explanation of autosomal recessive inheritance

2. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Here are some PowerPoint teaching slides which demonstrate the transmission of an autosomal recessive condition from parent to child, please feel free to use these within your teaching Some parts of the animations run automatically; others require a mouse click Most slides have notes with further information

3. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Hundreds of genes are located on each chromosome (The dark bands on the chromosomes are due to a special staining technique and are not genes as these are too small to see) The 46 human chromosomes seen down the microscope

4. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre The 46 human chromosomes arranged in their 23 pairs (these are the chromosomes of a normal male)

5. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Position of particular gene Chromosome pair

6. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre Has the condition Unaffected carrier for the condition Altered gene Usual gene

7. Parents Sperm or eggs Autosomal recessive inheritance where both parents are carriers Carrier for the condition

8. Parents Sperm or eggs At conception Autosomal recessive inheritance where both parents are carriers Carrier for the condition

9. Parents Sperm or eggs At conception Autosomal recessive inheritance where both parents are carriers Carrier for the condition Does not have the condition, non-carrier Carrier for the condition Has the condition Carrier for the condition

10. Genetics and genomics for healthcare www.geneticseducation.nhs.uk © 2013 NHS National Genetics and Genomics Education Centre This animation is part of a series describing modes of inheritance To access these and other resources for teaching and learning genetics, please visit: www.geneticseducation.nhs.uk