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IFPAC Real-time In-line Process Monitoring of Liquid Chemical Concentration Doug Nordstrom and Dave Simko Swagelok Company IFPAC ® - 2008 22nd International.

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Presentation on theme: "IFPAC Real-time In-line Process Monitoring of Liquid Chemical Concentration Doug Nordstrom and Dave Simko Swagelok Company IFPAC ® - 2008 22nd International."— Presentation transcript:

1 IFPAC Real-time In-line Process Monitoring of Liquid Chemical Concentration Doug Nordstrom and Dave Simko Swagelok Company IFPAC ® - 2008 22nd International Forum Process Analytical Technology January 27-30, 2008 Baltimore, Maryland

2 IFPAC Outline Refractive index and refractometers General applications Specific applications - Ultrahigh-purity liquids - Biopharmaceutical manufacturing NeSSI compatibility

3 IFPAC Refractive Index LIGHT SOURCE SUBSTANCE REFLECTED BEAM

4 IFPAC Refractive Index Fundamental physical property Measure of bending of a light beam moving from one medium to a more dense medium Ratio of sines of angles of incidence and refraction Constant for pure substance at STP Influenced by temperature and wavelength

5 IFPAC Refractometers Traditional handheld Digital handheld Abbe Inline process

6 IFPAC CR-288 ® Concentration Monitor

7 IFPAC General Applications Ultrahigh-purity liquids Monitoring bulk chemical feed quality and content Chemical blending, dilution, and spiking Controlling specific manufacturing processes Monitoring and controlling waste treatment

8 IFPAC General Applications Biopharmaceutical manufacturing Monitoring CIP solutions – chemical content and endpoint Chromatographic separation units – buffers, biological materials, and effluents PAT – Monitoring and controlling liquid chemical concentrations from substrate buffers and media to compounding

9 IFPAC TMAH 2.38% DIW High Resolution TMAH Measurements

10 IFPAC TMAH Monitor, 2.38% or 0.060% High Resolution TMAH Measurements

11 IFPAC EKC Continuous Dilution to Process

12 IFPAC EKC Dilution Results

13 IFPAC

14 IFPAC Three Chemical Blend with DI Water

15 IFPAC Photovoltaic Cell Manufacturing

16 IFPAC Feed Forward System - Slurry and H 2 O 2

17 IFPAC

18 IFPAC

19 IFPAC Refractive Index vs. Protein Concentration

20 IFPAC Cholesterol in TBME

21 IFPAC Ethanol/Proponal Repeatability

22 IFPAC CIP Solution

23 IFPAC Ultra Small Scale Leak Detection

24 IFPAC NeSSI Compatibility ANSI/ISA 76.00.02 FOOTPRINT CR-288 FOOTPRINT

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