1. Reporting on Scientific Journal Articles Jeremy Moore, M.A. Senior Manager, Science Communications American Association for Cancer Research jeremy.moore@aacr.org

2. Why is Cancer Newsworthy?

3. Number 1 cause of death, surpassing heart disease in 2010

4. Why is Cancer Newsworthy? Number 1 cause of death, surpassing heart disease in 2010 In the United States, it affects one in three women and one in two men

5. Why is Cancer Newsworthy? Number 1 cause of death, surpassing heart disease in 2010 In the United States, it affects one in three women and one in two men Consequences both biological and psychological

6. Why is Cancer Newsworthy? Money

7. Why is Cancer Newsworthy? Money Government Money –NCI Budget, 2009: $4.96 billion –NCI Budget, 2010: $5.1 billion

8. Why is Cancer Newsworthy? Money Government Money –NCI Budget, 2009: $4.96 billion –NCI Budget, 2010: $5.1 billion Budget Request for 2011 $5.26 Billion

9. Why is Cancer Newsworthy? Money Private Money

10. Why is Cancer Newsworthy? Money Private Money Corporate and Philanthropic

11. Scientific Inquiry “In fact I have not failed 1,000 times. I have successfully discovered 1,000 ways not to make a light bulb.” --Thomas Edison

12. Scientific Inquiry Cancer

13. Scientific Inquiry Cancer Out of control cell growth

14. Scientific Inquiry Cancer Out of control cell growth More than 200 diseases

15. Cancer CURE?

16. Cancer CURE vs. CONTROL

17. Cancer: The Scientific Questions Diagnosis

18. Bladder Cancer Pancreatic Cancer Ovarian Cancer Breast Cancer Colon Cancer Skin Cancer

19. Cancer: The Scientific Questions Diagnosis Screening

20. Questions surrounding PSA, Mammography, Colonoscopy

21. Sensitivity vs. Specificity Sensitivity Correctly Identifying Who Is Sick Specificity Correctly Identifying Who Is Not Sick

22. MicroRNA “The discovery of MicroRNA can be equated with the idea that we’ve known for years that cars existed and only recently discovered they have a transmission. It’s that fundamental.” Philip Sharp, Ph.D., Nobel Laureate from M.I.T.

23. MicroRNA News from Annual Meeting 2010 miR-21 and miR-106a are associated with an overall poor prognosis and that overexpressions of miR-181b and miR-203 are associated with poor outcomes in blacks for colorectal cancer MicroRNA-31 (miR-31) repressed specific tumor suppressors and, therefore, may be a novel pharmacologic target for lung cancer therapy and chemoprevention.

24. MicroRNA News from Annual Meeting 2010 High levels of miR-21 were significantly correlated with poor response to Herceptin.

25. DNA Methylation Levels

26. Cancer: The Scientific Questions Diagnosis Screening Personalized Medicine

28. Cancer: The Scientific Questions Diagnosis Screening Personalized Medicine Prevention

29. “At least half of all cancer deaths are preventable by what we already know about healthy eating, exercise, maintaining appropriate weight, avoiding smoking and going for regular screenings.” Ernest T. Hawk, M.D., M.P.H. Vice President of the Division of Cancer Prevention and Population Sciences at The University of Texas M. D. Anderson Cancer Center.

30. Prevention Healthy Living

31. Prevention Healthy Living Chemoprevention

32. Prevention

33. Scientific Inquiry 75 Clinical Trials & 11 Systematic Reviews Are Being Published Every Single Day Bastian H, Glaszio P, Chalmers I, et al. (2010). Seventy-Five Trials and Eleven Systematic Reviews a Day: How Will We Ever Keep Up? PLOS Med 7 (9): e1000326. doi:10.1371/journal.pmed.1000326.

34. Journals to Watch New England Journal of Medicine

35. Journals to Watch New England Journal of Medicine Journal of the American Medical Association

36. Journals to Watch New England Journal of Medicine Journal of the American Medical Association Cancer

37. Journals to Watch New England Journal of Medicine Journal of the American Medical Association Cancer Journal of Clinical Oncology

38. Journals to Watch Cancer Research

39. Journals to Watch Cancer Research Clinical Cancer Research

40. Journals to Watch Cancer Research Clinical Cancer Research Cancer Epidemiology, Biomarkers & Prevention

41. Journals to Watch Cancer Research Clinical Cancer Research Cancer Epidemiology, Biomarkers & Prevention Cancer Prevention Research

42. Journals to Watch Cancer Research Clinical Cancer Research Cancer Epidemiology, Biomarkers & Prevention Cancer Prevention Research Molecular Cancer Research Molecular Cancer Therapeutics

43. NEWS FLASH CANCER DISCOVERY

44. NEWS FLASH CANCER DISCOVERY –Officially announcing next week

45. NEWS FLASH CANCER DISCOVERY –Officially announcing next week –Editors in Chief, Jose Baselga, M.D, Ph.D. and Lewis Cantley, Ph.D.

46. NEWS FLASH CANCER DISCOVERY –Officially announcing next week –Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis Cantley, Ph.D. –Will be the premier venue for the publication and broad dissemination of high impact research in all areas of cancer research

47. NEWS FLASH CANCER DISCOVERY –Officially announcing next week –Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis Cantley, Ph.D. –Will be the premier venue for the publication and broad dissemination of high-impact research in all areas of cancer research. –First papers will be published online April 2011

48. NEWS FLASH CANCER DISCOVERY –Officially announcing next week –Editors in Chief, Jose Baselga, M.D., Ph.D., and Lewis Cantley, Ph.D. –Will be the premier venue for the publication and broad dissemination of high-impact research in all areas of cancer research –First papers will be published online April 2011 –In Print July 2011

49. THE ANATOMY OF AN ABSTRACT Conclusions, not titles

50. THE ANATOMY OF AN ABSTRACT Conclusions, not titles Goals

51. THE ANATOMY OF AN ABSTRACT Conclusions, not titles Goals Population Samples

52. THE ANATOMY OF AN ABSTRACT Statistics –P Values, anything less than.05 is significant

53. THE ANATOMY OF AN ABSTRACT Statistics –P Values, anything less than.05 is significant –Hazard Ratios –HR=1.23, 95% CI, 1.05-1.10

54. THE ANATOMY OF AN ABSTRACT

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57. KEEP IN TOUCH Jeremy Moore Senior Manager, Science Communications Office: 267-646-0557 Cell: 609-519-0212 jeremy.moore@aacr.org

58. THANK YOU