1. WarmMark ®2 and ColdMark ®2 Testing Procedures

2. WarmMark 2 Temperature Testing Procedure Tools: Circulating water bath with temperature accuracy of ±0.5°C and stability of 0.1°C Oven/Warmer (only in case the product threshold temperature is above ambient) Method: 1. Set the bath circulator to the stated stop temperature of the product (see table below). Make sure the temperature inside the bath has stabilized at the set point value. 2. Adhere all test products to a rigid paper or plastic card using the supplied adhesive. Place the test products inside a waterproof plastic bag. 3. This section is to be followed only when the product threshold temperature is above ambient: I - Set the oven to any temperature above the product threshold temperature. Temperature should not exceed +60°C. II - Place the bag with the products inside the oven for 5 - 10 minutes. III - Remove the plastic bag with the products out of the oven and immediately arm products as instructed in #4. Arming Window Breach Window

3. WarmMark 2 Temperature Testing Procedure, Cont’d 4. Arm test products by a firm squeeze on each product blister through the plastic bag. Verify that the arming window shows a dark blue line, which widens rapidly, revealing the word ON (in white). 5. Immediately after arming, submerge the bag with the test products into the liquid bath. Make sure the product is completely submerged under the liquid level for the entire duration of the test. The open side of the bag should be left above the liquid level keeping the inside of the bag dry. All visual referencing is to be done without removing the product from the liquid. 6. Wait at the stop temperature for a time period which is twice as long as the shortest printed time- mark (i.e. in case the shortest printed time mark is 1/2 hr., wait 1 hr. In case it is 1 hr., wait 2 hr., etc…). Verify that the color front has not progressed into the breach window after the time cycle. This confirms that the indicator has stopped and the colorant is in a solid form. 7. Increase the bath circulator temperature to +1.5°C above the product threshold temperature. Verify that the colorant has progressed into the breach window within the time period defined in #6. Arming Window Breach Window

4. WarmMark 2 Time Testing Procedure Tools: Controlled environment chamber with temperature accuracy of ±1°C Temperature data logger Method: 1. Place temperature data logger into the controlled environment. 2. Set the controlled environment to 2°C above the stated/printed threshold temperature. Make sure the temperature has stabilized. 3. Adhere all test products to a rigid paper or plastic card using the supplied adhesive. 4. This section is to be followed only when the product Threshold temp is above ambient: I - Preheat the bag with the products at the conditions in step #2 for a minimum of 5-10 minutes. II - Remove the plastic bag with the products out of the controlled environment and immediately arm products as instructed in #5 Printed Time Marks

5. WarmMark 2 Time Testing Procedure, Cont’d 5. Arm test products by a firm squeeze on each product blister. Verify that the arming window shows a dark blue line, which widens rapidly, revealing the word ON (in white). 6. Note the time of arming. The time of arming will be defined as elapsed time zero. 7. Place the product immediately inside the controlled environment close to the temperature data logger. 8. Verify that the colorant has reached each printed time mark within ±15% of the elapsed time. Optional - Photograph the test products at both 15% prior and 15% after each of the representative printed time lines. Do not remove the products from the environment for longer than 30 seconds. For example: The colorant line should reach the 1 Hr print mark (i.e. 60 minutes) between 51 minutes and 69 minutes. This correlates to ±15% in time. 9. Repeat this procedure for subsequent print marks. 10. Download the temperature profile from the temperature data logger and confirm that the temperature during the entire test matches the set point. Printed Time Marks

6. ColdMark 2 Testing Procedure Tools: Refrigerated circulating water bath with temperature accuracy of ±0.5  C and stability of 0.1  C (The test may be performed using an environmental chamber instead of a water bath) Temperature data logger Method: 1. Set the bath circulator to +2˚C above the threshold temperature of the ColdMark 2 indicator. Make sure the temperature inside the bath has stabilized at the set point value. 2. Adhere the test products to a rigid plastic card by using the adhesive on the back of the product. All products need to be oriented similarly on the card. Verify that none of the products shows red coloration in the arming and/or breach window. 3. Orient the plastic card vertically such that the product blister is above the blue breach window as illustrated on the product (THIS WAY UP). Breach Window Arming Window

7. ColdMark 2 Testing Procedure, Cont’d 4. Arm test products in a temperature environment (room temp) above the descending threshold temperature by firmly squeezing each product blister between two fingers (one finger on blister and the other below the card). Note: Do not apply pressure to the indication window once the product is activated. 5. Note that the small, round silver arming window turns red. The arming window does not necessarily remain red after releasing the squeeze from the activation blister. 6. Verify that none of the armed products shows red coloration in the breach window. Replace any such product with a new product and make note of any units that have shown immediate activation. 7. Photograph the card with all armed indicators. 8. Place the card with the products submerged vertically (THIS WAY UP) into the stabilized liquid bath for a period of up to five hours as oriented in stage 3. The soaking period can be reduced to a minimum of 1 hour to facilitate shorter testing cycle times.

8. ColdMark 2 Testing Procedure, Cont’d 9. After soaking period, remove the card out of the bath (still oriented vertically) and photograph the entire card with all indicators visible. 10. Verify that the breach window has not changed its color to red. Replace card into the bath. 12. Decrease the bath temperature by 0.5˚C increments at timed intervals (60 minutes for the 0˚C indicator or 30 minutes for the 2˚C indicator). At the end of each time interval, remove card from water bath (vertically) and photograph the condition of all indicators. Sequentially, replace card into bath. 12. Continue this procedure for up to four 0.5˚C increments below the threshold temperature. Keep checking until all indicator-windows show a stained red pattern confirming that the lower threshold temperature has been breached. The stained red pattern is dependent on the indicators orientation during freezing. 13. Note the breach temperature of each product and verify that this breach occurred within the product specification (±1˚C).