1. Diabetes Insipidus By: Abigail Wells and Samantha Wright

2. What is it? Loss of control of water balance Kidneys do not reabsorb excess fluid Tubules are not permeable to water Person experiences excessive thirst & urination

3. Cause Results from lack of vasopressin Damage to hypothalamus or pituitary caused by histiocytes

4. Cause Tumor in pituitary or hypothalamus Inflammation of hypothalamus and pituitary Osmoreceptors fail to work.

5. Diagnosis Blood Glucose Levels Bicarbonate Levels Calcium Levels

6. Diagnosis Fluid Depravation Test Excessive fluid intake Defect in ADH production Defect in kidney response to ADH

7. Diagnosis Changes in body weight Urine output Urine composition No fluid given, dehydration occurs

8. Diagnosis Normal Response = more concentrated urine, less frequent urination DI response = urinate large amounts of undiluted urine

9. Treatments Desmopressin Synthetic replacement for Vasopressin Nasally, intravenously, pill

10. Treatments Carbamazepine Anti-convulsive medication Had some success

11. Works Cited http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/K/Kidneys.gi f http://www.3dchem.com/imagesofmolecules/Vasopressin.jpg http://www.health-choices-for- life.com/images/Pituitary_hypothalamus.jpg http://assets.aarp.org/external_sites/adam/graphics/images/en/198 25.jpg http://www.health.bcu.ac.uk/physiology/ADH2.gif http://scienceblogs.com/startswithabang/upload/2009/04/putting_th e_yellow_in_your_uri/urine-contents.jpg http://wwwdelivery.superstock.com/WI/223/1598/PreviewComp/Sup erStock_1598R-198877.jpg http://www.drugs.com/images/pills/mtm/DDAVP%200.1%20mg.jpg http://www.healthcentral.com/common/images/l/LMM01090_46124 _5.JPG