1. Clinical Research Center at a Glance Lynda Lane MS Administrative Director

2. Clinical Research Center Funded through a grant from the National Center for Research Resources – NIH for the past 53 years. Formerly the GCRC. Purpose: to provide infrastructure support for clinical research. Part of the Clinical and Translational Science Award (CTSA) Access resources and support through the StarBRITE website. www.mc.vanderbilt.edu/starbrite www.mc.vanderbilt.edu/starbrite

3. Vanderbilt Institute for Clinical and Translational Research (VICTR) Establish physical and virtual home for translational investigation Stimulate/streamline communications and remove impediments Develop a new generation of investigators Actively develop novel methodologies Gordon Bernard, MD CTSA PI

4. Clinical and Translational Research Center Facilities Clinical Research Center 19 bed Inpatient and Outpatient facility Located on hospital space – S 3100 MCN Pediatric Clinical Research Center 6 Room Outpatient clinic Located in the Vanderbilt Children’s Hospital Clinic 9 th Floor DOT Clinical Trials Center 2 room outpatient clinic Office space for 15 research personnel Located at the Village at Vanderbilt New office at 100 Oaks Mall

5. CRC Investigators by Department

6. Nursing Core MCN location Staffed 24/7 Pedi CRC staffed M-F 26 Full time inpatient and outpatient nurses 2 Unit clerk 2 administrative support staff

7. Cardiovascular Physiology Autonomic Testing System Vascular and Cerebral Doppler Microneurography System Echocardiograph - Ultrasound ECG Forearm Blood Flow Systems Tilt Table EndoPat

8. Energy Balance and Exercise Physiology Bicycle Ergometers ● Treadmills Metabolic Carts DXA Scanner Metabolic Chamber BodPod Bioelectrical Impedance Activity Monitors

9. Bionutrition Assessment Metabolic Kitchen –Controlled nutrient meals Dieticians for meal planning Food analysis software

10. Informatics Lab Poster Printing Physiological Equipment Development Computer and software Support

11. Assay Development and Core Lab Imaging Satellite PET Imaging fMRI - 3 and 7 tesla

12. Two inpatient rooms configured for sleep monitoring systems EEG Polysomnograms Multiple sleep latency Sleep Research Core

13. What can the CRC Provide ? Pilot funding support Inpatient and outpatient space and nursing care Ancillary support for pilot projects

14. Grant Budget Planning for VICTR / CRC resources For grant budget planning, if you are submitting an investigator-initiated proposal funded by a federal grant, agency, or foundation, you may assume that the following support is available to you at no cost from the VICTR Clinical Research Center

15. Clinical Research Center and Pediatric CRC CRC Space and Nursing Centrifuge Use Dry Ice for Shipping Samples Freezer Space for Short-Term Sample Storage Inpatient Space and Nursing Care Outpatient Nursing Care on CRC Outpatient Space on CRC Pediatric Outpatient Nursing on Pedi CRC Pediatric Outpatient Space on Pedi CRC Ultrasound Technician CRC

16. Nutrition Services Diet Assessment - Outpatient Diet Instruction - Outpatient Food Records and Food Recalls Training Nutrition Counseling Nutrition Data System - Training Nutrition Data System for Research - Use Regular Meal/Snack Special Nutrient Controlled Meal Study Diet Development

17. Physiologic Measurement Metabolic Cart 24 Hour Energy Expenditure (Chamber) Actigraphy Actigraphy set up Bioelectrical Impedance Bod Pod DEXA Doppler Blood Flow Equipment EKG Without Interpretation Echocardiograph Equipment Exhaled Nitric Oxide Analyzer Forearm Blood Flow Equipment Physical Activity Monitoring Pedometers Tilt Testing Treadmill Testing -VO2 Max

18. Grant Management Must avoid double-dipping OK to state in grant proposal that Vanderbilt has a CRC that provides support. Can get letter of support for grant proposals

19. Vanderbilt Institute for Clinical & Translational Research (VICTR) Supported Weekly Clinics a No registration necessary. b Email notification of upcoming attendance helpful – contact biostat-clinic@list.vanderbilt.edu.biostat-clinic@list.vanderbilt.edu c See http://biostat.mc.vanderbilt.edu/Clinics for more details, including daily themes.http://biostat.mc.vanderbilt.edu/Clinics d By appointment – contact Erica Bowton, erica.bowton@vanderbilt.edu.erica.bowton@vanderbilt.edu e Contact Veida Elliott, veida.elliott@vanderbilt.edu, for available session dates.veida.elliott@vanderbilt.edu f See http://www.mc.vanderbilt.edu/crc/workshop.html for schedule of topics & presenters.http://www.mc.vanderbilt.edu/crc/workshop.html

20. How do I get support? StarBRITE www.mc.vanderbilt.edu/starbrite www.mc.vanderbilt.edu/crc