1. Genome generation

2. Timetable for today TimeActivity 00:00Introduction to the session 00:10Story cards 00:20Info cards 00:30Issue cards 00:40Discuss two key issues 00:45Feedback your issues

3. What is DNA?

4. TA G DNA’s code C

5. What is a gene? Coding DNA Non-coding DNA Protein

6. What is a genome?

7. G C TA G T C GATAG Genetic variation C C TA G T C TATAGC

8. Sequencing technology Sequencing technology is advancing rapidly. In 10 years DNA sequencing will become part of routine medical screening. Image by Roy Kaltschmidt, LBNL.

9. What is genotyping? Genotyping involves looking at particular regions of the genome that are known to vary between individuals. Information from genotyping can indicate: – disease risk – drug responsiveness – carrier status for disease – personal traits such as eye colour. Image by Kat M Research, Flickr.

10. What is genome sequencing? Genome sequencing involves finding out the whole sequence of a person’s DNA. Commercially available personal genome sequencing currently costs between £6,000 and £12,000. Image courtesy of Wellcome Library, London

11. Genes vs environment A predisposition means that people with a particular genotype tend to have an increased risk of developing a disease. Lifestyle plays a significant role in increasing or decreasing the risk of developing some diseases. Monogenic Type 2 Diabetes Obesity Infectious Disease Environment Genes

12. Story cards (10 minutes)

13. What is pharmacogenomics? What is schizophrenia? The genetics of breast cancer What are the risk factors for heart disease? What is flucloxacillin? How much can genetics alone really tell you? Are personalised medicines the drugs of the future? About the risk gene ApoE-e4 Genetic counselling Info cards (10 minutes)

14. Issue cards (10 minutes) How would you feel…? Who should know…? But, what if…? Is it right that…? Is it better to know…? What would you do…?

15. Top issues (5 minutes) Decide what are the two top issues that come out of the scenario. Highlight these as they will be used in feedback session. Remember to write notes throughout the discussion.

16. Discussion guidelines Speak for yourself and not for others. Allow others to finish before you speak. Listen well. Ask questions (???) as well as making statements (!!!) Explain what you think and feel. Respect differences in opinion. Find where you agree. Share your life experiences and knowledge – it is valuable.

17. Genome generation