1. Your Company Name Procedure Education DAVID DIMARCO MD

2. Your Company Name VenaCure EVLT, a 45- minute, in-office procedure requires only a local anaesthetic and enables patients to return to normal activity immediately – with little or no pain DAVID DIMARCO MD

3. Your Company Name Pre-EVLT 2 Wks Post-EVLT DAVID DIMARCO MD

4. Your Company Name Superficial Venous Insufficiency Etiology of Primary Disease DAVID DIMARCO MD

5. Your Company Name Higher incidence in women than men: –Up to 25% of all women suffer –Up to 15% of all men suffer 100 - 150 million people in US and Europe Not all are treated but 1 million surgical “stripping” procedures are performed in US and Europe annually Obesity, pregnancy, age & prolonged standing add to the problem How Common are Varicose Veins? DAVID DIMARCO MD

6. Your Company Name What Causes Varicose Veins? DAVID DIMARCO MD

7. Your Company Name Pre-EVLT2 Wks Post-EVLT DAVID DIMARCO MD

8. Your Company Name What happens when the Valves Fail? Valves in the vein lack the apposition needed to prevent reverse flow of blood down your leg Prolonged dilation damages the valves, so even when vasoconstriction occurs, the blood continues to flow in the wrong direction The resulting backpressure is termed “venous hypertension”, and this is what causes the painful varicosities DAVID DIMARCO MD

9. Your Company Name Surgical Treatment Stripping and Ligation Groin incision, ligation and tying off of tributaries and GSV Once the “stripper” is tied in place, the surgeon rips the stripper and the vein from the leg DAVID DIMARCO MD

10. Your Company Name Problems with Stripping and Ligation of the GSV The procedure must be done under general anesthesia in a hospital setting Most patients suffer from severe post-operative pain requiring prescription drugs to cope Severe bruising/ tenderness along the treated vein Typical recovery is between 2-4 weeks There is a high failure/ reoccurrence rate associated with this procedure DAVID DIMARCO MD

11. Your Company Name Treating Saphenous Vein Reflux The search for less invasive techniques to treat varicose veins has led to the development of EVLT® Endovenous Laser Treatment Diomed 810 nm Diode Laser DAVID DIMARCO MD

12. Your Company Name Pre - EVLT2 Wks Post - EVLT DAVID DIMARCO MD

13. Your Company Name 2 Mo. Post - EVLT Pre - EVLT DAVID DIMARCO MD

14. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

15. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

16. Your Company Name Pre – EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

17. Your Company Name The VenaCure EVLT Procedure Under local anesthesia,a catheter is placed in the vein through a needle The laser is passed through the catheter to the top of the vein After injection of additional anesthesia along the length of the vein, the laser is fired, and the catheter is withdrawn back out of small puncture site DAVID DIMARCO MD

18. Your Company Name Post-Operative Care Dress leg with compression bandage Class II compression stocking 20 minute walk Resume normal activities –Avoid hot baths –Avoid vigorous gym workouts OTC analgesics for any pain-Tylenol, Motrin DAVID DIMARCO MD

19. Your Company Name Examinations done with ultrasound to confirm vein staying closed: –At one week –At one, three and six months –Yearly thereafter Additional cosmetic treatment as needed –Sclerotherapy/ Phlebectomy Follow Up Care DAVID DIMARCO MD

20. Your Company Name What Can I Expect After My Procedure Mild Bruising can occur along the leg that has been treated A “tightening” sensation along the vein is reported by many patients Some mild tenderness along the vein for a couple of days is common Tylenol / Motrin is typically all that is needed DAVID DIMARCO MD

21. Your Company Name Have there been studies done to prove the safety and efficacy of VenaCure EVLT? Absolutely….let’s take a look DAVID DIMARCO MD

22. Your Company Name Endovenous Laser Treatment - Results 98% (686/701) closed at 3 - 42 months 223 limbs followed at least 2 years demonstrate continued occlusion Min R, Khilnani N, Zimmet. Endovenous laser treatment of saphenous vein reflux: long-term results. JVIR 2003; 14: 991-996. Over ½ a Million procedure performed globally DAVID DIMARCO MD

23. Your Company Name Pre-Treatment 2 month Post - EVLT DAVID DIMARCO MD

24. Your Company Name VenaCure EVLT® The Results 495 GSV’s treated in 423 Patients 98% initial technical Success, more than 93% remain closed over 2 years Well tolerated by all patients under strictly local anesthesia Endovenous Laser Treatment of Saphenous Vein Reflux: Long-Term Results Robert J. Min, MD, Neil Khilnani, MD, and Steven E. Zimmet, MD J Vasc Interv Radiol 2003; 14:991–996 DAVID DIMARCO MD

25. Your Company Name VenaCure EVLT The Results Combined Results Min, et al. > 3000 GSVs treated with endovenous laser Up to 28 month follow-up > 97% of GSVs have remained closed Bruising & mild/moderate tenderness (< 2 wks) No other minor or major complications DAVID DIMARCO MD

26. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

27. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

28. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

29. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

30. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

31. Your Company Name Pre - EVLT 2 Mo. Post - EVLT DAVID DIMARCO MD

32. Your Company Name Advantages Proven-safe, in-office procedure Well-tolerated with local anesthesia Non-scarring with minimal access site size Immediate return to daily activities Lower treatment costs compared to surgery DAVID DIMARCO MD