1. Automated Insulin Preparation System Progress Report Group 22: Brant Cauthorn, Jessica Filderman, and Kellie Stoka Client: Dr. Klaesner

2. Product Need  Prevalence  366 million people worldwide 1  Cost  $465 billion a year worldwide 1  50% of people inject insulin wrong 2  Why people do it wrong:  Visual Impairment  Peripheral Neuropathy  Arthritis 1Chang, Maria. The Huffington Post, 13 September 2011. 2Wartburg, Linda. Diabetes Health, 21 March 2009.

3. Design Requirements  General:  Small size  Inexpensive  Can be used in a home setting  Limited complexity  Operation:  Safe  Accurate  Not limited by user health conditions  Room Temperature  Minimum functions:  Hold two 10 ml insulin vial(s)  Mix insulin vial(s)  Sterilize vial(s)  Uncap needles  Insert needle into vial(s)  Withdraw a specified amount of insulin

4. Design Process  Optional Features  Injection Capability?  Temperature Control?  Blood Glucose Monitor?  Storage of Vials?  Data Communication?  Dose Verification?  Required Features  User Interface  Dose Vessel  Mixing  Sterilization  Setting Dose  Power Source

5. Design Alternatives – Optional Features  Injection Capability?  No  Temperature Control?  No  Blood Glucose Monitor?  No  Storage of Vials?  Yes  Data Communication?  Yes  Dose Verification?  Yes

6. Design Alternatives – User Interface Keypad Manual“Keys” Barcode Scanner External Computer Voice Recognition

7. Design Alternatives – User Interface User InterfaceWeightKeypadManualKeys Barcode Scanner External ComputerSpeech Ease of Use10879 57 Reliability810 985 Dose Increment710689 Range of Dose Input710689 Cost77975109 Availability6899104 Size57798109 Total432386430433398418

8. Design Alternatives - Mixing  Conveyor Belts  Drop Down Slot  Vortex  Vertical Arm Shaker  User Mixing  Tilt Shaker  Horizontal Platform Shaker

9. Design Alternatives - Mixing MixingWeight Conveyer Belts Drop Down SlotVortex Arm Shaking Vertically User Mixing Tilting PlatformShaker Storage Capability10 0 0 Compatability99108 Complexity981066 87 Accuracy797771088 Reliability791076998 Size689861087 Cost689861088 Speed589881088 Total515452460447483517495

10. Design Alternatives - Sterilization  Spray top of vial with isopropyl alcohol  Wipe top of vial with isopropyl alcohol pad  Dip top of vial in isopropyl alcohol  Heat top of vial  User sterilizes vial

11. SterilizationWeightSprayingWipingDippingHeatUser Effectiveness109 84 Reliability1088864 Cost9988810 Size9999910 Complexity8997710 Necessary Input?876610 Total 460453437429420 Design Alternatives - Sterilization

12. Design Alternatives - Container  What will hold the insulin?  Syringe  Insulin Pen Cartridge  Catheter

13. Design Alternatives - Container ContainerWeightSyringe Insulin Pen CartridgeCatheter Cost81069 Pain to User68107 Ease of Use10895 Reliability810 7 Sterility10 96 Availability71067 Size5798 Portability64100 Total517515369

14. Design Alternatives - Syringe  Traditional Syringe  Significant user difficulty  Modified Syringe  Moderate user difficulty  New Syringe Design  Minimal user difficulty ???

15. Design Alternatives - Syringe  New Syringe Design

16. Design Alternatives - Syringe Syringe TypeWeightTraditionalModifiedNew Ease of Use1057 Reliability10 Accuracy10 Cost91098 Size810 Total420431452

17. Design Alternatives – Setting Dose and Drawing Up Insulin  Stepper Motor  Spacers  Bar  Pressure

18. Design Alternatives – Setting Dose and Drawing Up Insulin Setting DoseWeightMotorSpacersBarPressure Accuracy108886 Two types of insulin possible?10 5 9 Sterility910 Reliability88886 Speed/duration78668 Complexity of design78886 Cost68568 Size610888 Total554460516482

19. Design Alternatives – Dose Verification  Weight  Weigh vials before and after drawing insulin  Use density to determine volume change  Light  Shine light through syringe, measure absorption  Raise light vertically until absorption changes (Insulin-air interface)

20. Design Alternatives – Dose Verification Dose VerificationWeight Weight SolutionLight Solution Compatibility10 9 Reliability958 Accuracy988 Design complexity885 Cost7109 Size7109 Total421400

21. Chosen Design

22. Next Steps  Select materials and parts  Determine precise assembly of parts  What happens if machine malfunctions  Choose convenient locations for supply input  Machine waste removal

23. Schedule

24. Team Responsibilities  Brant – Website Design and Maintenance, CAD Drawings  Kellie – Material & Manufacturing Requirements, CAD Drawings  Jessica – Risk Analysis, Report Editing

25. Questions?