1. Approach to Chest Pain

2. History

3. “When it comes to chest pain, if you aren’t confident with your diagnosis after your history, take it again” Dr. M. Gamble

4. OLD CARS

5. O: onset L: location D: duration C: character A: associated/aggravatin g/alleviating R: radiation S: sex

6. Are cardiac risk factors useful in evaluating the risk of ACS?

7. Registry Data 10 806 ED visits for ACS (good definitions) Risk factors: – Smoking – DM – HTN – Dislipidemia – Family History

10. In patients over 40, cardiac risk factor burden is of limited clinical value in the diagnosis of ACS In patients under 40, cardiac RF useful if there are none (-LR 0.17) or if there are 4 or more (+LR 7.39)

11. How useful are clinical features in the diagnosis of acute, undifferentiated chest pain?

12. Prospective study of 893 pts presenting to ED with CP Tested the power of clinical features to predict AMI (WHO criteria) and ACS (cardiac testing, AMI, death, or revascularization within 6 months). Conclusions: 1.AMI: –Exertional pain (LR: 2.35) –Pain radiating to shoulder or both arms (LR: 4.07) –Chest wall tenderness (LR: 0.3)

13. ACS: –Exertional Pain (LR: 2.06) –Pain radiating to shoulder or left arm, or both arms (LR: 1.62) Location of the pain, quality and presence of N/V or diaphoresis were not predictive

14. Right arm involvement? Berger, J. 1990. J Intern Med. 277(3) Prospective study of 278 ED pts with CP –100 MI –47 UA –25 SA –106 non-coronary disease Most specific feature for MI: –Right arm radiation 51 pts with right arm radiation 47 had coronary disease (41 MI’s)

15. What is the predictive and prognostic value of the ECG in patients with ACS?

16. Non-specific ST and T wave changes –ST segment depression or elevation of < 1mm with or without an abnormal T wave –T wave may have altered morphology and/or blunted, flattened, or biphasic configuration without inversion or hyperacuity Normal –Absence of NSSTTW, AV block, intraventricular conduction delay, repolarization changes, and rhythms other than NSR

17. CP in the ED with a normal ECG: –1% final diagnosis of AMI –4% final diagnosis of UA Another study – typical chest pain pts: –3% final diagnosis of AMI NSSTW findings: –3-4% of AMI pts –20% of NSTEMI/UA pts Therefore, of all patients with ACS, one fifth will show a normal or non-specific ECG in the ED

19. Of 202 chest pain patients presenting to the ED with STE, 15% had an AMI LVH was the most common cause of STE (25%), followed by LBBB (15%) and AMI (15%) 12% had BER, 5% had RBBB, and 5% had nonspecific BBB Other less common diagnoses were LVA, pericarditis, and paced rhythm

20. GUSTO-IIb trial data Over 12,000 patients who had ACS confirmed on ECG 22% had T wave inversion, 28% had STE, 35% had STD, and 15% had a combination of the above 30 day incidence of death or MI: –TWI: 5.5% –STE: 9.4% –STD: 10.5% –STE & STD: 12.4%

21. 50% of patients with AMI will have a clearly diagnostic ECG at presentation (STE or STD) ST segment elevation identifies those who benefit from reperfusion therapy (lytics) Mortality increases with the number of leads showing STE RV infarcts complicate 40% of inferior AMIs

22. What is the utility of cardiac biomarkers in diagnosing ACS?

23. 2 h4h6h8h10h12h Troponin Sensitivity 204575829598

24. Chest Pain & Crashing Pt ABC’s & Vitals ECG/CXR ACS Esophageal Rupture (Aortic Dissection) (PE) EDE Tamponade Shock & Absent breath sounds PTx

25. Goodacre et al. How Useful are Clinical Features in the Diagnosis of Acute, Undifferentiated Chest Pain? Academic Emergency Medicine, vol. 9, no. 3, 2002. Features Predictive of AMI: Thanks Adam

26. Goodacre et al. How Useful are Clinical Features in the Diagnosis of Acute, Undifferentiated Chest Pain? Academic Emergency Medicine, vol. 9, no. 3, 2002. Features Predictive of ACS: Thanks Adam