1. Figure 1A ADV ADV+LAM 0 2 4 6 8 HBV DNA (Log IU/mL) 0 100 200 300 400 500 ALT (IU/mL) A Months of therapy M0M7M14M21M28M35M42M48M56

2. Figure 1B 0 2 4 6 8 10 0 200 400 600 800 1000 ADV ADV+LAM HBV DNA (Log IU/mL) ALT (IU/mL) B Months of therapy M0M5M10M15M20M25M30M35M40M45

3. Figure 1C ADV 0 2 4 6 8 10 0 100 200 300 400 500 HBV DNA (Log IU/mL) ALT (IU/mL) C Months of therapy M0M5M10M15M20M25M30M35M40M45

4. Figure 1D 0 2 4 6 8 0 100 200 300 400 500 ADV HBV DNA (Log IU/mL) ALT (IU/mL) D Months of therapy M0M5M10M15M20M25

5. Figure 1E E ADV ADV + LAM 0 2 4 6 8 0 100 200 300 400 500 HBV DNA (Log IU/mL ) ALT (IU/mL) Months of therapy M0M7M14M21M28M35M42

6. Figure 1F F 0 2 4 6 8 0 100 300 200 ADV HBV DNA (Log IU/mL) ALT (IU/mL) Months of therapy M0M10M20M30M40M50

7. Figure 1G G 0 2 4 6 8 10 0 200 400 600 800 1000 ADV ADV+LAM HBV DNA (Log IU/mL) ALT (IU/mL) Months of therapy M0M7M14M21M28M35M42M48