1. BLOOD CELL IMAGES

2. Light microscopy image showing an eosinophil among red blood cells. Eosinophils are granulocytes, specialised white blood cells with highly granular cytoplasm and a multi-lobed nucleus. Produced in the bone marrow, eosinophils migrate to tissues, attracted by chemicals released at sites of cell destruction. They defend against parasites, and are phagocytic. Credit: Spike Walker, Wellcome Images. BIGPICTUREEDUCATION.COM Eosinophil and red blood cells

3. Digital artwork of a single white blood cell (leukocyte). These cells circulate in the blood around the body and target sites of infection. There are different types of white blood cells that carry out specific roles within the immune system. Credit: Maurizio De Angelis, Wellcome Images. White blood cell

4. False-colour light microscopy image of human T cells. Credit: Wellcome Images BIGPICTUREEDUCATION.COM T cells

5. False-colour scanning electron micrograph of a human white blood cell (leukocyte) on a mesh of fibrin. Fibrin is an important protein in the formation of blood clots. Credit: Anne Weston, LRI, CRUK, Wellcome Images BIGPICTUREEDUCATION.COM White blood cell

6. False-colour transmission electron micrograph of a small lymphocyte surrounded by a number of red blood cells. Credit: University of Edinburgh, Wellcome Images. BIGPICTUREEDUCATION.COM White and red blood cells

7. False-coloured transmission electron micrograph of a leukocyte (white blood cell). Nuclear lobes are shown by the label B. Credit: David Gregory and Debbie Marshall, Wellcome Images BIGPICTUREEDUCATION.COM White blood cell

8. False-coloured scanning electron micrograph image of a lymphocyte and a red blood cell. Credit: Wellcome Images. BIGPICTUREEDUCATION.COM Lymphocyte and red blood cell

9. Enhanced confocal microscope image of lymphocytes (red), comprising natural killer cells and T cells, which are migrating between and through cultured endothelial cells (outlined in green). The lymphocytes can move both between the endothelial cells and straight through their cytoplasm. Endothelial cells line the blood vessels, and this migratory mechanism allows the lymphocytes to move rapidly from the blood out into the tissues when required. Credit: Dr David Becker, Wellcome Images. BIGPICTUREEDUCATION.COM Transmigration of lymphocytes

10. Light microscopy image of bone marrow. Red blood cells can be seen in red. Credit: Ivor Mason, Wellcome Images. BIGPICTUREEDUCATION.COM Bone marrow

11. Light microscopy image showing a normal blood film with red blood cells and several white blood cells (leukocytes). Blood films are small amounts of blood smeared across a slide and examined under the microscope. They can be used to investigate disorders of the blood and some parasitic infections, including malaria. Credit: Wellcome Images. BIGPICTUREEDUCATION.COM Blood film

12. Digital artwork showing microscopic detail of red blood cells, platelets and white blood cells. Credit: Wellcome Images. BIGPICTUREEDUCATION.COM Blood cells

13. Scanning electron micrograph of red blood cells clearly showing their biconcave disc shape. Credit: Annie Cavanagh, Wellcome Images. BIGPICTUREEDUCATION.COM Red blood cells

14. Reusing our images Images and illustrations All images, unless otherwise indicated, are from Wellcome Images. Contemporary images are free to use for educational purposes (they have a Creative Commons Attribution, Non-commercial, No derivatives licence). Please make sure you credit them as we have done on the site; the format is ‘Creator’s name, Wellcome Images’.Creative Commons Attribution, Non-commercial, No derivatives licence Historical images have a Creative Commons Attribution 4.0 licence: they’re free to use in any way as long as they’re credited to ‘Wellcome Library, London’.Creative Commons Attribution 4.0 licence Flickr images that we have used have a Creative Commons Attribution 4.0 licence, meaning we – and you – are free to use in any way as long as the original owner is credited.Creative Commons Attribution 4.0 licence Cartoon illustrations are © Glen McBeth. We commission Glen to produce these illustrations for ‘Big Picture’. He is happy for teachers and students to use his illustrations in a classroom setting, but for other uses, permission must be sought. We source other images from photo libraries such as Science Photo Library, Corbis and iStock and will acknowledge in an image’s credit if this is the case. We do not hold the rights to these images, so if you would like to reproduce them, you will need to contact the photo library directly. If you’re unsure about whether you can use or republish a piece of content, just get in touch with us at bigpicture@wellcome.ac.uk.bigpicture@wellcome.ac.uk