1. Introduction of Medical Imaging Chun Yuan

2. Organization of the Course 8 Lectures (1.5 hours per lecture) – Introduction of medical imaging and MRI – Basic concept of image formation – Basic pulse sequences and contrast manipulation – Image Reconstruction – RF pulse and gradient pulse – Fast imaging and advanced applications – MRI hardware – Functional MRI

3. Text Books Magnetic Resonance Imaging - Physical Principles and Sequence Design – ISBN: 0-471-35128-8 – Authors:E. M. Haacke, R. W. Brown, M. R. Thompson, and R. Venkatesan – Publisher:John Wiley and Sons, 1999 Handbook of MRI Pulse Sequences – ISBN: 0-7803-4723-4 – Authors:Bernstein, King, and Zhou – Publisher:Elsevier Publishing, 2004

4. Credits Home work – One for each day – 60% Term project – Topics will be provided – 40%

5. What is Medical Imaging Introduce some form of radiation – electromagnetic – Acoustic Observe its interaction with tissue – attenuation – scattering / reflection – Concentration Convert the observations into a clinically meaningful image – film – computer

6. Electromagnetic Spectrum

7. Imaging Considerations Type of information – anatomical - from head to toe – functional - cardiac, brain, etc. – quantitative vs. qualitative Limitations – resolution – sensitive range (e.g. view angles) – speed – cost – invasiveness

8. “Classical” methods Projection Radiography (Conventional X-ray) Ultrasound Conventional Nuclear Medicine Images that are direct manifestations of the interaction between radiation and tissue

9. Projection Radiography Physical Principle: Variation in X-ray attenuation of different tissues Methodology: A beam of X-rays is directed through a patient onto a film. Image: An X-ray “shadow” of the patient. History: – Roentgen’s discovery - 1895 – Application to medicine – 1896 – contrast materials - early 1900’s – angiography - 1927

10. Projection Radiography System

11. Projection Radiography Examples Chest X-Ray Mammogram Angiogram

12. Ultrasound Physical Principle: Ultrasound waves scatter and reflect within the body Methodology: A pulse of ultrasonic energy is propagated into the body and backscattered echoes record the depth of objects in the body. Image: A “depth map” of patient organs. History: – Concept derived from W.W.II sonar – Major clinical development - 1970’s

13. Ultrasound System

14. Ultrasound Mode B-mode image – Longitudinal view of digital artery – Frequency: 40MHz – Resolution: up to 50mm Doppler – Flow velocity in digital artery

15. Nuclear Medicine Physical Principle: Variable uptake of radioactive materials by different organs Methodology: Inject patient with radiolabeled substance and record time-space pattern of radiation. Image: A map of the radioactivity of the patient. History: – Therapeutic administration of radiolabeled substances - 1950 – Scintillation camera - 1952

16. Nuclear Medicine System

17. Nuclear Medicine Example

18. “Computed” methods Computed Tomography (CT) – X-ray CT – PET – SPECT Magnetic Resonance Imaging (3D Ultrasound) Images that are formed using mathematical methods and computers from indirect measurements of the interaction between radiation and tissue

19. Computed Tomography Physical Principle: Projection slice theorem dictates how to reconstruct a 2-D image from multiple 1-D projections (Radon Transform). Methodology: Obtain multiple projection images and reconstruct images using a computer. Image: A 2-D slice mapping the patient’s X-ray attenuation coefficient (X-ray CT) or radioactivity (PET and SPECT). History: – X-ray CT proposed - mid 1960’s – Early clinical use - 1972 – PET and SPECT followed X-ray CT

20. Computed Tomography System

21. X-ray CT Example

22. PET Example

23. Magnetic Resonance Imaging Physical Principle: Within a strong magnetic field, paramagnetic nuclei (usually hydrogen protons) will resonate in response to RF radiation Methodology: Place patient in a magnet, irradiate with RF field, and record spatially encoded RF echoes. Image: A map of proton concentration through a slice of the body. History: – NMR discovered - 1940’s – Imaging proposed in 1972 – Current generation of machines developed in 1980’s

24. Nobel Prize for MRI

25. MRI System

26. MRI Example

27. Star Artifacts in CT

28. Shadow Artifacts in Ultrasound

29. Wrap-around Artifacts in MRI