1. The Use Of Electronic Laboratory Notebooks To Automate Manual Data Collection Processes Robert D. Walla Presented At PITTCON 2003 Orlando, FL Astrix Technology Group Global Solutions Provider To The Regulated Community

2. Develop And Integrate Data Management Solutions For Scientific Organizations Astrix Technology Group  Data Collection LIMS Development And Customization Instrument Workstations PDA Applications – Remote Data Collection  Data Storage Data Warehouse Solutions Data Synchronization Remote Access Via Web  Data Retrieval Data Miming Statistical Analysis Reporting

3. Astrix Technology Group

4. Benefits Of Electronic Data Capture Astrix Technology Group  Increases Researcher And Organizational Efficiency  Increases Quality By Eliminating Manual Data Entry and Resulting Transcription Errors  Knowledge Retention  Facilitates Access To Data Across The Enterprise  Decreases Product Development Cycles  Decreases Costs

5. Laboratory Automation Market Observations Market Observations Astrix Technology Group

6. Laboratory Automation The Early Years Astrix Technology Group  Data Kept In Paper Form o Notebooks o Instrument Printouts o Strip Charts  Tremendous Strides in the Automation of Analytical Techniques

7. Laboratory Automation 1980 - 1999 Astrix Technology Group  Improvements in Data Capture And Processing From Automated Instruments (i.e. Chromatography Data Acquisition Systems)  Introduction Of LIMS o Initially Internally Developed Systems o Commercial LIMS Vendors o Expanded System Functionality To Address Administrative Requirements, i.e. Sample Tracking, Reporting, Financials, etc.

8. The Modern Laboratory Astrix Technology Group  Still An Incredible Volume Of Paper Sample Prep Logs QA/QC Logs Observational Analysis Diagrams/Drawings/Pictures Researcher Notes  Electronic Laboratory Notebooks Envisioned As The Next Generation System

9. Drivers Astrix Technology Group  Elimination of Re-Work (30-70% in Research Environments)  Ability To Use and Share Negative Results  High Throughput Screening of Materials and Formulations  Regulations  Workforce Turnover/Knowledge Retention

10. What is an Electronic Lab Notebook? Astrix Technology Group  Mobile PDA Application?  Standalone PC Application?  Data Warehouse?  LIMS?  Document Management System?  Scientific Data Management Systems?

11. Case Studies Case Studies Astrix Technology Group

12. Electronic Notebook That Collects Process Water Chemistry and Equipment Operational Data. Used by Customers To More Efficiently Manage Cooling Water Systems, Including Functionality For Trend Analysis, Benchmarking and Predictive Modeling. Case Study 1 Client: Global Water Treatment Company

13. Case Study 1 Global Water Treatment Company Electronic Notebook  PC Based Application  Introduced in 1998  Deployed In Over 3000 Sites In 12 Countries  Used By Company Representatives  Installed At Client Facilities  Provided Valuable Functionality To Client  Company Used Data To Predict System Failures  Reduced Total Operational Cost

14. Case Study 1 Electronic Notebook Allowed Customers To View And Analyze Trends

15. Case Study 1 Success A Company Vice President stated “The implementation of Astrix’s system leveraged over $ 7.5 million in increased sales for our Industrial Services Division in one year.” A Company Vice President stated “The implementation of Astrix’s system leveraged over $ 7.5 million in increased sales for our Industrial Services Division in one year.”

16. Electronic Notebook To Collect Physical, Performance And Exposure Data On Architectural And Automotive Finishes. Developed To More Efficiently Capture And Share Research And Development Data. Included The Integration Of Existing Data Systems. Case Study 2 Client: Global Coatings Company

17. Case Study 2 Global Coatings Company Electronic Notebook  PDA Application  Developed Using Visual Basic  Used By 120 Scientists  Data Synchronization To Data Warehouse  Desktop Application Printed Paper Copy For Inclusion In Paper Lab Notebook  Linked Data From LIMS At Manufacturing Sites  Developed Web Query Application

18. Case Study 2

19. Coating and Colorings Data Warehouse System Topology

20. Commercial Electronic Notebook Data Capture Product That Collects GLP Regulatory Data For Chemical Registrations. Operates in 5 Languages and Being Used Worldwide By 70% of The Agrichemical Industry. Case Study 3

21. Agrichemical Industry Electronic Notebook  Tablet PC Application  Introduced in 1995  Used by Over 70% of the Agrichemical Market  Fortune 50 Chemical Companies  Independent Contract Research Organizations  Over 7000 Trials Conducted With FieldNotes  GLP Compliant  Passed EPA Audits and Regulatory Submissions  Operates In Five Languages

22. Measurable ROI Dr. John Murphy, Director of Residue Chemistry, Bayer Corporation said "Our Program was budgeted at $2.41 million dollars. We were able to conduct the program for $1.43 million. We would not realized these efficiency gains had we not had Astrix’s assistance. Even with the cost of this assistance factored in we saved $970,000.” Dr. John Murphy, Director of Residue Chemistry, Bayer Corporation said "Our Program was budgeted at $2.41 million dollars. We were able to conduct the program for $1.43 million. We would not realized these efficiency gains had we not had Astrix’s assistance. Even with the cost of this assistance factored in we saved $970,000.” Case Study 3

23. Astrix Technology Group  Despite The Advance In Automation There Remains Significant Manual Data Collection Processes  Electronic Notebooks Are “What You Need Them To Be”  Technology (Hardware/Software) Is Available And Improving  Progressive Companies Are Taking Iterative Steps And Realizing Near Term Benefits and ROI Conclusions

24. Astrix Technology Group Comments or Questions: Robert D. Walla 732-661-0400 www.astrixsoftware.com

25. Astrix Technology Group Global Solutions Provider To The Regulated Community