1. PATHOPHYSIOLOGY OF NERVE Dr. Ayisha Qureshi Assistant Professor MBBS, Mphil

2. EFFECTS OF CUTTING A MIXED NERVE:

3. What will happen if you cut a mixed nerve?

4. 1.LOSS OF MOTOR ACTIVITY: Affected muscles become paralyzed & show reflex activity Muscles become flaccid (NO TONE) Rapidly undergo loss of mass (WASTING) Muscles start showing the ERB’S REACTION OF DEGENERATION: altered response of the muscles to electrical stimulation seen after loss of motor supply. 2.LOSS OF SENSATIONS: NO sensation in the area of the cut sensory nerves.. 3. LOSS OF AUTONOMIC NERVE ACTIVITY: Area becomes blue & cold. Activity of the sweat glands comes to an end. 4.LOSS OF TROPHIC ACTION: (growth-promoting action) Atrophy (loss of mass & wasting) of the muscles that were supplied by the motor nerves.

6. DEGENERATION & REGENERATION OF NERVE FIBRES

7. DEGENERATION: When a nerve fibre is cut or severely crushed, degenerative changes take place at 3 levels: 1.Changes in the nerve cell body 2.Changes in the central/proximal stump (RETROGRADE DEGENERATION) 3.Changes in the distal stump (WALLERIAN DEGENERATION also called the Secondary Degeneration)

8. 1. Changes in the nerve cell body: Cell body swells Nissl granules undergo dissolution (CHROMATOLYSIS) Nucleus is pushed to one side Mitochondria, Golgi apparatus, ribosomes & lysosomes show structural changes If the axon is cut quiet close to the cell body, the neuron may die....

9. 2. RETROGRADE DEGENERATION This is the degeneration that occurs in the central or proximal segment. Degenerated area may extend upwards for one or more nodes. Degeneration my be followed by repair...... As this part is still attached to the cell body.

11. REGENERATION: Regeneration of injured nerve fibres will take place in 2 cases: 1.If the injury was slight and/ or away from the cell body. 2.If the injured nerve fibre was part of the PNS. WHAT HAPPENS: The nissl granules reappear & the nucleus resumes its central position. Full recovery may take upto 3-6 months. The endoneural tube is formed by the Schwann cells themselves. This tube guides the regenerating nerve fibre to its proper destination. At the beginning of the process, axon in the central end of the cut nerve fibers elongate & give rise to large no. Of fibrils that enter into the endoneural tube.

14. Steps of Regeneration:

16. What is a Neuroma? If the gap between the 2 ends of a crushed nerve fibre is more than 3 mm, the nerve fibres tend to intermesh and form a tumor like swelling called Neuroma. This is very painful in the case of sensory nerves.

17. NO REGENERATION IN CNS: Regeneration DOES NOT take place in optic nerve and in the CNS due to the following reasons: 1.The endoneural tubes are absent in the CNS as there are no schwann cells are present; so the regenerating axons cannot be guided. 2.The oligodendrocytes cannot aid in regeneration as the schwann cells. 3.The activity of the astrocytes results in the formation of scar tissue.

18. MULTIPLE SCLEROSIS:

19. Multiple Sclerosis: Going, Going, Gone….. It is an auto-immune disease in which there is patchy loss of myelin sheath of nerve fibers leading to disruption of nerve impulse conduction. Cause: Antibodies mistakenly attack and destroy Schwann cells, thus also destroying the myelin sheath. Signs & symptoms: Patchy destruction of myelin in the CNS→ slow & abnormal conduction of the nerve impulses in the neurons ↓ 1.Visual disturbances 2.Tingling & numbness 3.Muscle weakness & Fatigue 4.Gradual paralysis 5.Bladder & bowel problems

23. Treatment Debilitating disease but not fatal. The quality of life is affected…. Death may occur when the paralysis reaches the respiratory muscles and the person cannot breathe. No treatment as yet. Only symptomatic treatment.  Immunosuppressive therapy: as autoimmune disease so you try to suppress the immune system to prevent further damage.  Corticosteroids  Alternative therapy: as homeopathy, ayurvedic treatment etc