1. Breast Cancer By: Vincent Russo And Scott Jeffery

2. Introduction Impact Impact What is Breast Cancer? What is Breast Cancer? Breast Cancer Symbol

3. Effected Areas Ductal Cancer Ductal Cancer Carry Milk Carry Milk Lobule Cancer Lobule Cancer Make Milk Make Milk

4. Genes Involved BRCA-1 BRCA-1 Breast cancer early onset Breast cancer early onset BRCA2 BRCA2 Tumor suppressors Tumor suppressors Tumor Suppressor- help prevent cells from grow and dividing too rapidly or in an uncontrolled way. Tumor Suppressor- help prevent cells from grow and dividing too rapidly or in an uncontrolled way. CDH1 CDH1 Instructions Epithelial Cadherin Instructions Epithelial Cadherin E-Cadherin- binds cells to make tissue E-Cadherin- binds cells to make tissue PTEN PTEN Instructions Proteins Instructions Proteins

5. Genes ( Continued) STK11 STK11 InstructionsSerine/threonine kinase 11 InstructionsSerine/threonine kinase 11 Serine/threonine kinase 11- prevents tumors Serine/threonine kinase 11- prevents tumors  TP53  Instructions P53 Tumor Suppressor

6. Symptoms Lumps Lumps Swelling Swelling Rash Rash Itchy/Dry Itchy/Dry Red or Blotchy Red or Blotchy

7. Diagnosis Mammogram Mammogram Breast MRI Breast MRI Biopsy Biopsy

8. Stages Stage 0- cancer has not spread (non-invasive) Stage 0- cancer has not spread (non-invasive) Stage I- cancer spreads to different areas (invasive) Stage I- cancer spreads to different areas (invasive) Up to 2 centimeters Up to 2 centimeters No lymph nodes involved No lymph nodes involved  Stage II- invasive IIA- cancer cells are in axillary lymph nodes, not in breast OR tumor is up to 2cm, spread to axillary lymph nodes OR larger than 2cm less than 5cm to axillary lymph nodes IIA- cancer cells are in axillary lymph nodes, not in breast OR tumor is up to 2cm, spread to axillary lymph nodes OR larger than 2cm less than 5cm to axillary lymph nodes IIB- tumor larger than 2cm less than 5cm and has not spread to axillary lympth nodes OR larger than 5cm and has not spread to axillary lymph nodes IIB- tumor larger than 2cm less than 5cm and has not spread to axillary lympth nodes OR larger than 5cm and has not spread to axillary lymph nodes

9. Stages (Continued)  Stage III- Invasive  IIIA- spread to lymph nodes near breast bone, OR 5cm or less and spread to other structures, Or larger than 5cm and spread to other structures.  IIIB- any size and spread to chest wall and/or skin, OR may spread to axillary lympth nodes clumped to other structures, may spread to lympth nodes near breastbone  IIIC- may have no sign of cancer in breast, if so may spread to chest wall or skin OR spread to lympth nodes above or below collorbone AND may spread to axillary lympth nodes or lympth nodes near breastbone  Stage IV- spread to other organs (invasive)

10. Complications Blockage Blockage Spreading Spreading

11. Prevalence/Epidemiology Age Age Gender Gender Ethnic Group Ethnic Group Statistics Statistics

12. Prevention Check Breasts Check Breasts Annual Examines Annual Examines Mammograms Mammograms Drugs/ Smoking/ Alcohol Drugs/ Smoking/ Alcohol Exercise Exercise

13. Treatment Chemotherapy Chemotherapy Radiation Radiation Therapy Therapy

14. Awareness Walks Walks Commercials Commercials Commercials Sponsors Sponsors Days Days

15. Any Questions??

16. Thank you for listening to our presentation. Hope you learned some new information.

17. Work Cited "Breast Cancer Side Effects." Cancer Compass. Rising Tide, Kft., n.d. Web. 15 Feb. 2010.. Henderson, Roger, Dr. "Breast Cancer." Net Doctor. Netdoctor.co.uk, 6 May 2009. Web. 15 Feb. 2010.. "Stages of Breast Cancer." Breast Cancer.org. Breastcancer.org, 21 Jan. 2010. Web. 15 Feb. 2010.. "Symptoms and Diagnosis." Breast Cancer.org. Breastcancer.org, 27 June 2009. Web. 15 Feb. 2010..