1. INSULIN IMAGES

2. A model of the insulin molecule. The two chains are shown in different colours. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose concentrations. It also increases cell fatty acids. Defects of insulin are the cause of hyperinsulinaemia and type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images Molecular model of insulin molecule

3. A model of the insulin molecule shown as a ribbon diagram. Each chain is shown in a different colour. The disulphide bonds are shown in yellow. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose concentrations. It also increases cell fatty acids. Defects of insulin are the cause of hyperinsulinaemia and type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images BIGPICTUREEDUCATION.COM Molecular model of insulin molecule

4. A model of the insulin molecule shown as a ribbon diagram. Each chain is shown in a different colour. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose concentrations. It also increases cell fatty acids. Defects of insulin are the cause of hyperinsulinaemia and type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images BIGPICTUREEDUCATION.COM Molecular model of insulin molecule

5. A model of the insulin molecule. The alpha-helices are represented as cylinders. Insulin molecules consist of two polypeptide chains (A and B) linked by disulphide bonds. Insulin decreases blood glucose concentrations and increases cell permeability to monosaccharides, amino acids and blood glucose concentrations. It also increases cell fatty acids. Defects of insulin are the cause of hyperinsulinaemia and type 2 diabetes mellitus. Credit: T Blundell and N Campillo, Wellcome Images BIGPICTUREEDUCATION.COM Molecular model of insulin molecule

6. Woman injecting herself with insulin to control diabetes. Credit: Wellcome Photo Library, Wellcome Images BIGPICTUREEDUCATION.COM Insulin injection

7. This photomicrograph shows a section through the pancreas of a person with an insulinoma (tumour of the pancreas). It shows substantial amounts of amyloid (pink) in the islets. The brown cells are beta cells secreting insulin. Credit: Anne Clark, University of Oxford, Wellcome Images BIGPICTUREEDUCATION.COM Insulinoma, amyloid deposits in pancreas islets

8. A transmission electron micrograph showing collagen fibrils in the sclera. At the top of the picture, they are seen in longitudinal section; towards the bottom, they are seen in transverse section. The attached proteoglycans are seen as fine filaments on the fibrils running radially, axially and around the fibrils. The fibrils are approximately 130 nm in diameter. Credit: Rob Young, Wellcome Images BIGPICTUREEDUCATION.COM Beta cells secreting insulin in a human pancreas

9. A photomicrograph of a section through a normal human pancreas, labelled for insulin. It shows the islets of Langerhans, which control insulin secretion, situated in a sea of exocrine tissue. The insulin is secreted by special groups of cells called beta cells. Insulin is involved in the regulation of sugar metabolism, being responsible for removing glucose from the blood by promoting glycogenesis and the uptake of glucose by respiring cells. Credit: Anne Clark, University of Oxford, Wellcome Images BIGPICTUREEDUCATION.COM Insulin secretion in islets of Langerhans

10. Dr Frederick Banting was a Canadian doctor who was awarded a Nobel Prize for discovering insulin with Professor John Macleod. Credit: Wellcome Library, London BIGPICTUREEDUCATION.COM Frederick Grant Banting

11. Reusing our images Images and illustrations All images, unless otherwise indicated, are from Wellcome Images. Contemporary images are free to use for educational purposes (they have a Creative Commons Attribution, Non-commercial, No derivatives licence). Please make sure you credit them as we have done on the site; the format is ‘Creator’s name, Wellcome Images’.Creative Commons Attribution, Non-commercial, No derivatives licence Historical images have a Creative Commons Attribution 4.0 licence: they’re free to use in any way as long as they’re credited to ‘Wellcome Library, London’.Creative Commons Attribution 4.0 licence Flickr images that we have used have a Creative Commons Attribution 4.0 licence, meaning we – and you – are free to use in any way as long as the original owner is credited.Creative Commons Attribution 4.0 licence Cartoon illustrations are © Glen McBeth. We commission Glen to produce these illustrations for ‘Big Picture’. He is happy for teachers and students to use his illustrations in a classroom setting, but for other uses, permission must be sought. We source other images from photo libraries such as Science Photo Library, Corbis and iStock and will acknowledge in an image’s credit if this is the case. We do not hold the rights to these images, so if you would like to reproduce them, you will need to contact the photo library directly. If you’re unsure about whether you can use or republish a piece of content, just get in touch with us at bigpicture@wellcome.ac.uk.bigpicture@wellcome.ac.uk