1. Figure S1: Mathematical model of CD14 signaling pathway

2. Figure S2: Mathematical model of PI3K signaling pathway

3. Figure S3: Mathematical model of TNF signaling pathway

4. Figure S4: Mathematical model of EGF signaling pathway

5. Figure S5: Mathematical model of MAPK signaling network ReactionSpeciesCompartment

6. Figure S6: Simulation graphs of (A) CD14 (B) TLR4 (A) (B)

7. Figure S7: Simulation graphs of (A) cytoplasmic NF-kappa B (B) EGF (C) TNF (A) (B) (C)

8. Figure S8: Simulation graph of entire MAPK network

9. (A) (B) (C) Figure S9: Simulation graphs of TRAF-6 crosstalk point in (A) TNF (B) CD14 (C) MAPK network

10. (A) (B) (C) (D) Figure S10: Simulation graphs of MKK3/6 crosstalk point in (A) TNF (B) CD14 (C) EGF (D) MAPK network

11. (A) (B) (C) (D) Figure S11: Simulation graphs of MKK4/7 crosstalk point in (A) TNF (B) CD14 (C) EGF (D) MAPK network

12. (A) (B) (C) Figure S12: Simulation graphs of PIP2 crosstalk point in (A) EGF (B) PI3K (C) MAPK network

13. Figure S13: Sensitivity plot of CD14

14. Figure S14: Sensitivity plot of TLR4

15. Figure S15: Sensitivity plot of IRAK4/1

16. Figure S16: Sensitivity plot of EGF

17. Figure S17: Sensitivity plot of TNF

18. Figure S18: Sensitivity plot of TRAF-6

19. Figure S19: Sensitivity plot of cytoplasmic NF-kappa B

20. PathwaysMean path lengthDiameterAverage paths EGF71326 TNF5922.6667 CD145914.333 PI3K71310.923 Table S1: Mean path length, diameter and average paths for individual pathways Clustering coefficient0.017 Diameter12 Radius1 Average paths10.31 Mean path length4.902 Number of nodes72 Number of edges88 Isolated nodes0 Self loops0 Table S2: Statistics of the MAPK network

21. ReactionsFlux cytoplasm.CD14 → cytoplasm.TLR40.485643 cytoplasm.TLR4 → cytoplasm.MyD880.211183 cytoplasm.[IRAK4/1] → cytoplasm.[TRAF-6]0.201431 cytoplasm.TNF → cytoplasm.TNFR0.369697 cytoplasm.[TRAF-6] → cytoplasm.ECSIT0.233653 cytoplasm.TAK1 → cytoplasm.[MKK4/7] 0.294193 cytoplasm.ASK1 → cytoplasm.[MKK3/6]0.265605 cytoplasm.[IkB/NF-kappa B] → cytoplasm.[NF-kappa B]0.337536 cytoplasm.EGF → cytoplasm.EGF_EGFR0.491873 cytoplasm.EGF_EGFR → cytoplasm.EGF_EGFR_EGF_EGFR0.229942 cytoplasm.MEK → cytoplasm.MEKp0.223247 nucleus.[ERK1/2] → nucleus.Elk0.216036 Table S3: Reactions with high flux values in the network

22. ReactionsSensitivity cytoplasm.CD14 → cytoplasm.TLR40.499 cytoplasm.TLR4 → cytoplasm.MyD880.581 cytoplasm.[IRAK4/1] → cytoplasm.[TRAF-6]0.399 cytoplasm.TNF → cytoplasm.TNFR0.524 cytoplasm.[TRAF-6] → cytoplasm.ECSIT0.614 cytoplasm.TAK1 → cytoplasm.[MKK4/7] 0.487 cytoplasm.ASK1 → cytoplasm.[MKK3/6]0.796 cytoplasm.[IkB/NF-kappa B] → cytoplasm.[NF-kappa B]0.714 cytoplasm.[NF-kappa B] → nucleus.[NF-kappa B]0.593 cytoplasm.EGF → cytoplasm.EGF_EGFR0.601 cytoplasm.EGF_EGFR → cytoplasm.EGF_EGFR_EGF_EGFR0.757 cytoplasm.MEK → cytoplasm.MEKp0.349 nucleus.[ERK1/2] → nucleus.Elk0.593 Table S4: Reactions having high sensitivity coefficient (Wi,j) values in the network