1. Skin Pigmentation Melanin in the Melanocyte Cells Eumelanin Black/Brown Pigment Pheomelanin Red/Yellow Pigment Response to UV Radiation Pigmented Cells Resistant to Damage by Sun Protected From Melanin Antioxidants Unpigmented Cells Sensitive to Sunlight Damage Protected by Glutathione/Selenomethionine Antioxidants

2. DEPIGMENTATION Properties of Glutathione/Selenium Protect Skin from UV Radiation which generate free radicals that cause skin damage and hyperpigmentation GSH redirects synthesis to the light (Pheomelanin) instead of the dark (Eumelanin) Inhibits enzyme tyrosinase that synthesizes dark melanins Skin Cell’s become more resistant to UV exposure (Brigarti, 2003) (Burke, 1997)

3. Skin Brightening Thione Complex™ lozenges with: Glutathione & Selenomethionine Plus Antioxidant Vitamins C & E And the Glutathione Depigmenting Enzymes A complement to the Skin Brightening Products Free Radical Scavenging Functions to Reduce UV Radiation to the Skin Works From Within To The Skin®

4. Melasma Blotchy Hyper-pigmentation of Face Associated with Pregnancy Topical Therapy Hydroquinone, Retinoic Acid Thione Complex™ Oral Therapy with Glutathione/Selenium Reduces UV Radiation Impact on Affected Skin Induces Glutathione Enzymes Promotes Synthesis of Clear Melanin Inhibits Tyrosinase Enzyme that Makes Dark Melanin

5. The Aging Skin Chrono-aging  Sagging Skin Photo-aging  Wrinkles and Pigmented Lesions Ultraviolet Radiation Acute: Sunburn Chronic: Oxidative Damage  Pre-malignant Lesions  (Keratosis, Moles)  Malignancy  Squamous/Basal Cells  Malignant Melanoma

6. Influence of Glutathione Levels in Melanin Synthesis Pathways to Melanin Synthesis High GSHLow GSH ↓  Eumelanin Eumelanin (Dark Pigment) (Dark Pigment) Conclusion: High GSH levels influence pathway toward the production of greater amounts of clear pigment (Pheomelanin) in skin cells