1. Weight Management Gene Expression Science

2. Advances in Gene Expression Science Allow Scientists to Compare & Contrast Expression Patterns of two Biological States Biological State #1Biological State #2 State

3. Comparison of Genetic Profiles of Adipose Tissue in Identical Twins Pietiläinen et al. PLoS Med. 2008 Mar 11;5(3):e51. Same DNA Different Expression of Genes Normal Weight Twin Overweight Twin Compared to their normal weight twin, overweight twins exhibited down regulation of gene expression pathways related to: Fat Regulation (storage versus utilization) Muscle Protein Synthesis

4. Nu Skin owns patented technologies to study anti-aging interventions through gene expression science Deep understanding of gene expression science

5. Identified Gene Expression Pathways Linked to Fat Storage and Fat Metabolism LifeGen pre-clinical study of Adipose, Gastrocnemius muslce, Hypothalamus

6. Ghrelin Leptin Insulin References: Gene Expression relates to the Appetite Control Center of the Brain Appetite Control Eating Behavior Regulation of energy intake 1.Smeets et al. Proceeding of the Nutrition Society. 2012;71:511-520. 2.Guthoff M, et al. J Clin Endocrinol Metab. 2010;95:748-755. 3.De Silva, et al. Cell Metab. 2011;14:700-706. 4.Malik S, et al. Cell Metab. 2008;7:400-409. 5.Farooqi IS, et al. Science. 2007;317:1355 6.Suzuki K, et al. Experimental Diabetes Research. 2012:1-19. 7.Viquerie N, et al. Diabetologia. 2005;48(1):123-131. 8.Mager et al. European Journal of Endocrinology. 2008;158: 9.Mutch DM, et al. Am J Clin Nutr. 2011;94(6):1399-1409.

7. Formulations Based on: Proprietary gene Expression Research The latest and most robust nutritional science

8. Eating Plan Based on: Protein Science & Nutrition Science Supports metabolically-active lean muscle and inhibits fat storage 1 Reference: Wycherley TP, et al. AJCN. 2012;96(6):1281-98. An eating plan designed to complement the supplements.

9. Carbohydrates (260g) Proteins (90g) Fats (67g) Typical Reduced Calorie Diet – 2000 kcal Fat Burning Foods Fat Storing Foods Carbohydrates (260 g) Proteins (90 g) Fats (67 g)

10. Carbohydrates (260g) Proteins (90g) Fats (67g) Typical Reduced Calorie Diet – 2000 kcal Fat Burning Foods Fat Storing Foods Carbohydrates (180 g) – 1200 kcal Fats (33 g) Proteins (45 g)

11. Carbohydrates (260g) Fats (67g) Proteins (90g) Eating Plan – 1200 kcal Fat Burning Foods Fat Storing Foods Proteins (90 g) Carbohydrates (260 g) Fats (67 g)

12. Carbohydrates (260g) Proteins (90g) Fats (67g) Fat Burning Foods Fat Storing Foods Carbohydrates (120 g) Fats (40 g) Eating Plan – 1200 kcal Proteins (90 g)

13. Eating Most of Your Protein with Only One Meal of the Day Limits Duration of Metabolic Burn FAT STORING FAT BURNING Time in Metabolic Burn Zone = Only 3 hours/day Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Breakfast LunchDinner ZONES

14. Eating Protein with Each Meal Accelerates Metabolic Burn FAT STORING FAT BURNING Adapted from: 1.Paddon-Jones and Rassmussen. Curr Opin Clin Nutr Metab Care, 2009;12:86. 2.Layman DL. Nutrition and Metabolism, 2009; 6:12. Breakfast LunchDinner Time in Metabolic Burn Zone = 9 hours/day ZONES

15. Open Label Clinical Study Participants Reported… -Lower levels of Hunger -Changes in body silhouette -Clothes fit better -Liked this program better than programs they had tried previously -90 Days on ingredients-based program -45 women and 21 men completed the study Results of unpublished preliminary study 2013

16. ageLOC TR90 Summary Healthy weight management and Body Shaping program. Based on gene expression science, addresses key factors related to weight management: -Healthy Metabolism, -Promotes Lean Muscle Maintenance -Appetite Control Studies on TR90 weight management program resulted in significant weight loss, fat loss and changes in gene expression.

17. 17 SIGNS & SYMPTOMS Nutrition Science Gene Expression Science Antioxidant Science

18. LIFEPAK—THE PERFECT COMPANION Nutritional foundation is important –LifePak ® provides that foundation Ensure adequate nutrition during reduced calorie regimen Dietary antioxidants for added protection from oxidative stress

19. LifePak Off-sets Oxidative Stress During Dieting Average SCS for study participants 10,000 20,000 30,000 40,000 36,000 30,000 29,000 Baseline6 Weeks12 Weeks Participants took LifePak Scanner Scores increase an average of 6,000 per person Data from My Victory Open-label Study 2007

20. AGELOC R 2 – The Perfect Companion Maintain energy levels Assist with cell renewal and cleansing during lipolysis

21. TR90 SUPPORT TOOLS

23. Create and communicate your personal transformation through a compelling story and transformation number that is completely unique to your ageLOC TR90 experience. WHAT’S YOUR TRANSFORMATION NUMBER?