1. Morinda citrifolia (Noni)

2. Major Component  Vitamin C, carotene, vitamin A  Potassium  Sterol  flavanoid

3. Biological activity  Antimicrobial Antibacterial: fruit, root Antiviral: root Anti TB: leaves Anti helmintic: ascaris: leaves  Antitumor activity: fruit juice Animal cancer Leukemia cell line

4.  Analgesic activity: animal  Antiinflammatory: in vitro cox-2 inhibitor  Hypotensive activity: root  Immunological: fruit Inhibit TNF-, stimulate IF, IL2  antioxidant activity Biological activity

5. Clinical Survey  67% of cancer(847) significant lessening symptoms  72% of overwt lose wt  87% of hypertensive has drop in BP  90% of chronic pain improve pain  80% arthritis improve symptom

6. Conclusion  Animal model or in vitro study  In human study: descriptive, subjective, byass

7. The effects of green tea consumption on incidence of breast cancer and recurrent of breast cancer: a systematic review and meta-analysis  Aim: determine the efficacy of green tea on risk of BC development and BC recurrent  SR and meta-analysis of observational studies 8 Integ Cancer Ther 2005, 4: 144-55

8.  Pool relative risk of developing BC in highest consumption 0.89 [0.71-1.1], p =0.28  In case control: OR 0.44 [0.14-1.31]. P=0.14  Subgroup analysis of recurrent in stge I, II pool RR 0.56[0.39-0.83] p=0.004  Dose response relationship The effects of green tea consumption on incidence of breast cancer and recurrent of breast cancer: a systematic review and meta-analysis Integ Cancer Ther 2005, 4: 144-55

9.  Consumption of > 5 cups of green tea/d shows non statistical sig trend towards prevention of BC  Green tea consumption may possibly help prevent breast cancer recurrence in stage I, II The effects of green tea consumption on incidence of breast cancer and recurrent of breast cancer: a systematic review and meta-analysis Integ Cancer Ther 2005, 4: 144-55

10. Conclusion of potential therapeutic application are currently impossible  Small number of studies  lack of clinical trial evidence  Lack of consistent dose-response relationship  Potential for interaction with standard care

12. Fatty Acid Content in Edible Oil % of total fat