1. RESEARCH TEAMS OF THE FUTURE Working Groups and Co-Chairs  Interdisciplinary Research Patricia Grady, NINR Ken Olden, NIEHS Larry Tabak, NIDCR  High-risk Research Ellie Ehrenfeld, NIAID Stephen Straus, NCCAM  Public-Private Partnerships Andy von Eschenbach, NCI Richard Hodes, NIA

2. Research Teams of the Future: Interdisciplinary Research Lawrence A. Tabak, D.D.S., Ph.D.

3. Multi- and Interdisciplinary Research “Just definitions either prevent or put an end to a dispute” Nathaniel Emm

4. Multi- and Interdisciplinary Research A B common problem Work on A B C A B Multidisciplinary Interdisciplinary Interaction forges new discipline

5. More is different P.W. Anderson, Science 177, 393-396, 1972

6. Multi- and Interdisciplinary Research will be Required to Solve the “Puzzle” of Complex Diseases and Conditions Genes Behavior Diet/Nutrition Infectious agents Environment Society ???

7. Interdisciplinary Research MathematiciansPsychologistsPhysicistsNursesEconomistsEngineersDentistsSociologistsPhysicians

8. Challenges to Interdisciplinary Research  The current system of academic advancement favors the independent investigator  Most institutions house scientists in discrete departments  Interdisciplinary science requires interdisciplinary peer-review  Project management and oversight is currently performed by discrete ICs  Interdisciplinary research teams take time to assemble and require unique resources

9. Research Teams of the Future: Current Roadmap RFAs  Interdisciplinary Research  Meetings and Networks for Methodological Development in Interdisciplinary Research  Training for a New Interdisciplinary Research Workforce  Supplements for Methodological Innovations in the Behavioral and Social Sciences  Interdisciplinary Health Research Training: Behavior, Environment and Biology  Short Programs for Interdisciplinary Research Training  Curriculum Development Award in Interdisciplinary Research  Exploratory Centers (P20) for Interdisciplinary Research  Public/Private Partnerships  High Risk Research  NIH Director's Pioneer Award

10. Exploratory Centers (P20) for Interdisciplinary Research  Purpose: to plan exploratory centers that overcome barriers to conducting interdisciplinary research  How? Applicant organizations must describe their plans to facilitate interdisciplinary research 1.How the institution will distribute credit for direct (and indirect) costs to reflect the contributions of different components 2.How the institution will recognize the contributions of the research team beyond the Principal Investigator 3.How the institution attends to the careers of "interstitial" team members who play important roles in interdisciplinary research, but who are not tenure track or eligible/appropriate to be principal investigators on research grants.

11. Supplements for Methodological Innovations in the Behavioral and Social Sciences  Purpose: to develop innovative methodology (research design, data collection techniques, measurement, and data analysis techniques) in social and behavioral sciences research.  What?  New technologies and the analytical complexities associated with the integration of behavioral, social, genetic, and biomedical data  Improved methods for performing research on diverse populations or on potentially sensitive or covert behaviors such as drug use, abuse, and violence  Innovative experimental designs to study how changes in economic, social, environmental, physical, or political context affect all aspects of ongoing research  Development and integration of behavioral and social sciences measures with those of the biomedical disciplines

12. Research Teams of the Future: Training, Career Development and High Risk Research Patricia A. Grady, Ph.D., R.N.

13. Transforming Research Training Interdisciplinary research training is a prerequisite to interdisciplinary research.

14. Transforming Research Training means:  Linkages among biological, behavioral, social, physical sciences  Collaboration between clinicians and scientists  Partnerships with industry

15. Research Teams of the Future: ’04 RFAs Interdisciplinary Research  Meetings and Networks for Methodological Development in Interdisciplinary Research  Training for a New Interdisciplinary Research Workforce  Supplements for Methodological Innovations in the Behavioral and Social Sciences  Interdisciplinary Health Research Training: Behavior, Environment and Biology  Short Programs for Interdisciplinary Research Training  Curriculum Development Award in Interdisciplinary Research  Exploratory Centers (P20) for Interdisciplinary Research High Risk Research  NIH Director's Pioneer Award

16. Training for Interdisciplinary Research Workforce  Develop and implement novel training programs  Build upon existing multidisciplinary and interdisciplinary institutional research programs  Prepare individuals to lead or engage in team approaches to solve complex health problems

17. Interdisciplinary Health Research Training: Behavior, Environment and Biology  Formal coursework and research training in a new interdisciplinary field for those having advanced degree in a different discipline  Required to have behavioral or social science discipline  Integration of behavioral/social with more traditional biomedical

18. Curriculum Development Award in Interdisciplinary Research  Support the development of innovative courses and curricula designed to train interdisciplinary scientists  Curricula can be designed for undergraduate, pre- doctoral or postdoctoral students, or combinations  Focus on programs that encourage the integration of quantitative, physical, behavioral, or social sciences with the traditional biomedical sciences

19. Short Programs for Interdisciplinary Training  Fusion of information, research practices and technologies  Promote training in “interdisciplines”  Students emerge with sufficient understanding of a new discipline that they can meld it with their previous training

20. High Risk Research To accelerate advances...  Encourage high risk/high impact research  Develop and test far-ranging ideas  Implement novel programs

21. TraditionalRoadmap  Outstanding individuals  High risk/high impact research  Novel programs

22. NIH Director’s Pioneer Award  New program to support individuals with untested, potentially groundbreaking ideas!  Encourages innovation, risk-taking  Totally new application and peer review process  Expected to be highly competitive  Expanded eligibility – (not only traditional biomedical investigators)  Provides $500,000/year for 5 years

23. Research involves taking risks