2. H + Secretion Parietal Cells GIP Growth of gastric mucosa Small peptides Disten- sion Vagus H+H+ Gastrin G Cells CCK I Cells Secretin S cells Stomach GRP Stomach Fatty Acids Oral gluc. Duodenum Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Biliary HCO 3 - secretion Insulin secretion Growth of exocr. pancreas (food bits) Inhibition loop Gallbladder contraction

3. H + Secretion Parietal Cells Growth of gastric mucosa Small peptides Disten- sion Vagus H+H+ Gastrin G Cells Stomach GRP Stomach Inhibition loop

4. Small peptides CCK I Cells Fatty Acids Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Growth of exocr. pancreas (food bits) Gallbladder contraction

5. H + Secretion Parietal Cells H+H+ Secretin S cells Fatty Acids Duodenum Pancreatic HCO 3 - secretion Biliary HCO 3 - secretion

6. H + Secretion Parietal Cells GIP Fatty Acids Oral gluc. Insulin secretion (food bits) Small peptides

7. H + Secretion Parietal Cells Growth of gastric mucosa Disten- sion Gastrin G Cells Stomach

8. H + Secretion Parietal Cells Growth of gastric mucosa Vagus Gastrin G Cells GRP

9. H + Secretion Parietal Cells GIP Growth of gastric mucosa Small peptides Gastrin G Cells CCK I Cells Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Insulin secretion Growth of exocr. pancreas Gallbladder contraction

10. H + Secretion Parietal Cells Growth of gastric mucosa H+H+ Gastrin G Cells Secretin S cells Stomach Duodenum Pancreatic HCO 3 - secretion Biliary HCO 3 - secretion Inhibition loop

11. H + Secretion Parietal Cells GIP CCK I Cells Secretin S cells Fatty Acids Pancreatic enzyme secretion Pancreatic HCO 3 - secretion Gastric emptying Biliary HCO 3 - secretion Insulin secretion Growth of exocr. pancreas Gallbladder contraction

12. H + Secretion Parietal Cells GIP Oral gluc. Insulin secretion

13. Growth of gastric mucosa Small peptides Disten- sion Vagus H+H+ Gastrin G Cells Stomach GRP Stomach

14. H + Secretion Parietal Cells GIP Small peptides Disten- sion Vagus H+H+ Gastrin G Cells Secretin S cells Stomach GRP Stomach Fatty Acids Oral gluc. Duodenum (food bits) Inhibition loop

15. Small peptides CCK I Cells Fatty Acids Growth of exocr. pancreas

16. Small peptides CCK I Cells Fatty Acids Gallbladder contraction

17. Small peptides CCK I Cells Fatty Acids Pancreatic enzyme secretion

18. Small peptides CCK I Cells Fatty Acids Gastric emptying

19. Small peptides H+H+ CCK I Cells Secretin S cells Stomach Fatty Acids Duodenum Pancreatic HCO 3 - secretion (food bits)

20. H+H+ Secretin S cells Stomach Fatty Acids Duodenum Biliary HCO 3 - secretion

21. GIP Fatty Acids Oral gluc. Insulin secretion (food bits)