1. What is a Systematic review?

2. Systematic review  Combination of the best research projects in a specific area Selecting Identifying Synthesizing  Health care sciences: Clinical tests Social interventions Medicine and healthcare Economic evaluations Public and health interventions

3. Traditional reviewSystematic review They are not led by peer-reviewed protocol and it is no possible to replicate the findings They are led by peer-reviewed protocol and it is possible to replicate the findings They are not explicit about how studies are selected, assessed and integrated They are explicit about how studies are selected, assessed and integrated Lack of rigorHigh quality of rigor Different conclusionsCommon conclusion between reviewers

4. Defining questions Searching literature Assessing studies Combining results Discuss results

7. Meta- analysis  Statistical research technique  Combination of: o Quantitative o Qualitative  Statistical difference between 2 treatments

8. Advantages 1.Overcoming bias. Narrative reviews could introduce bias. A meta-analysis can overcome these dangers. 2.Precision. These researches detect clinical significant effects. 3.Transparency. Allow readers to determine the reasonableness of the decisions taken.

9. Location of studies Quality assessment Effect size Avoid publication bias Sensitivity analysis