1. Second generation: Collamer™ (?) Fyodorov lens

2. Third generation: Staar ICL -Material: Hydrophilic collagen polymer (63% hydroxy- ethyl-methyl-acrylate; 0.2% porcine collagen; 3.4% benzofenone for UV absorption) -Water content: 34% -Refractive index: 1.45 -Optical zone: 4.5-5.5 mm -11.0-13.0 mm long; 7.0 mm wide -Thickness: 50  m at the optic zone; 500-600  m at the haptic zone; 100  m at the haptic footplates

3. Third generation: Staar ICL

4. Third generation: Medennium PRL -Material: Highly purified silicone -Refractive index: 1.46 -Optical diameter: 4.5-5.0 mm -10.8 or 11.3 mm long -6.0 mm wide -“One-size-fits-all” design -Not fixed in the ciliary sulcus; “floating” on the natural crystalline lens

5. Third generation: Medennium PRL

6. Phakic posterior chamber IOLs Cells involved in crystalline lens and capsular bag opacification Evolution of designs of PPCIOLs Relevant aspects of fixation and sizing Sizing issue: New studies Surgical implantation Relationship between cataract and myopia Cataractogenesis Specimens analyzed in our Center Mechanisms Review of the literature Classification of cataracts after phakic IOL implantation?

7. Second generation: Chiron-Adatomed silicone lens

8. Second generation: Chiron-Adatomed silicone lens

9. Third generation: Staar ICL -Consecutive “V” models with different vaulting characteristics in order to reduce the possibility of cataractogenesis -Correct lens sizing is important: too largeexcessive vaulting too smallinstability/decentration

10. Third generation: Staar ICL Oversized ICL F. Trindade, MD, PhD, “Proper size, positioning of ICL are crucial”, Ophthalmology Times, October 15, 2000; 106.

11. Third generation: Staar ICL F. Trindade, MD, PhD, “Proper size, positioning of ICL are crucial”, Ophthalmology Times, October 15, 2000; 106. Central vault/ midperipheral contact

12. Third generation: Staar ICL F. Trindade, MD, PhD, “Proper size, positioning of ICL are crucial”, Ophthalmology Times, October 15, 2000; 106. Undersized ICL

13. Third generation: Staar ICL Trindade F, Pereira F. Exchange of a posterior chamber phakic intraocular lens in a higly myopic eye. J Cataract Refract Surg 2000; 26:773-776 (Composite UBM)