1. Drugs effecting the digestive organs function Lector prof. Posokhova K.A.

2. Among substances that influence on functioning of digestive organs there are following groups of drugs: Drugs which influence on appetite; Emetic and antiemetic drugs; Drugs which are used in case of disturbed function of gastric glands; Drugs effecting liver function; Drugs used in case of disturbed excretory function of pancreas; Laxative agents; Drugs which influence on motor function of intestines

3. Drugs which influence on appetite: Drugs which improve improveappetite Drugs which depressappetite

4. Гіркоти Полин гіркий Золототисячник малий Деревій звичайний

5. Phepranonum Form of production - 0,025 g tablets

6. Mechanism of action of emetic and antiemetic drugs

7. Metoclopramide, reglan and cerucal From of production: 0,01 g tablets, ampoules with 2 ml of 0,5 % solution.

8. Motilium Form of production: 0,01 g tablets

9. Drugs which stimulate gastric secretion: With diagnostic aim: caffeine, histamine, gastrin. With treating aim: plantain juice, plantaglucide, natural gastric juice, pepsin, hydrochloric acid.

10. Drugs which depress gastric secretion: Drugs which block choline receptros: M-cholinoblockers (nonselective cholionolyutics): atropine sulfate M 1 -cholinoblockers with selective action (selective cholinolytics): gastrozepin ganglioblockers: pirilen, benzohexonium Drugs which block histamine-Н 2 -receptors: cimetidine, renitidine, famotidine, nizatidine, rexatidine Inhibitors of proton pump: omeprazole, controlok Prostaglandines and their synthetic derivatives: misoprostol Antacid drugs: System: sodium hydrocarbonate Nonsystem: aluminum hydroxide, magnesium oxide, almagel, maalox, renni Gastroprotectors: Drugs which form mechanic protection of mucous membrane of stomach: sucralfate, de-nol Drugs which increase protective function of mucous barrier and stability of mucous membrane towards action of damaging factor: carbenoxolon, misoprostol

11. Atropine sulfate (Atropini sulfas). Powder for preparation of 0,5 % and 1 % eye drops, 1% eye ointment, 0,0005 g tablets, ampoules with 1 ml of 0,1 % solution.

12. Gastrozepin (Gastrocepinum) Forms of production: 0,025 g and 0,05 g tablets; ampoules with 0,01 g of dry substance.

13. Cimetidine Form of production: 0, 2 g tablets.

14. Ranitidine (Ranitidin) Forms of production: 0,15 g and 0,3 g tablets and ampoules with 2 ml of 2,5 % solution.

15. Famotidin Forms of production: 0,02 g and 0,04 g tablets.

16. Omeprazole Form of production – 0,02 g capsules.

18. Antaciddrugs SystemantacidsNonsystemantacids

19. Almagel Combined drug which contains gel of aluminum hydroxide, magnesium oxide and D-sorbit. Form of production: 170 ml bottles.

20. Antacid drugs

21. Maalox Combined rugs which contains gel of aluminum hydroxide, magnesium oxide.

22. Sucralfate Form of production: 1 g tablets

23. De-nol Form of production: 0,12g tablets.

24. Pylobact Omeprazole + Clarythromycin + Tinidazole

25. Schemes of combined treatment of gastric ulcer De-nol + amoxycillin De-nol + metronidazole Omeprazole + amoxycillin + clarythromycin De-nol + clarythromycin + metronidazole De-nol + controlok + amoxycilin + clarythromycin

26. Drugs which influence on functioning of digestive organs Part 2

27. Among substances that influence on functioning of digestive organs there are following groups of drugs: Drugs which influence on appetite; Emetic and antiemetic drugs; Drugs which are used in case of disturbed function of gastric glands; Hepatotropic drugs; Drugs used in case of disturbed excretory function of pancreas; проносні засоби; Drugs which influence on motor function of intestines

28. Hepatotropicdrugs Jaundice (?) Liver protectors Cholelytholytic

29. Classification of жовчогінних drugs: Drugs which stimulate bile ptoduction (choleretics, cholesecretors) Drugs which increase secretion of bile and stimulate production of bile acids (true choleretics) а) drugs which include bile acids (allochol, cholenzyme) б) synthetic drugs (nicodine, oxafenamide) в) drugs of plant origin (безсмертник піщаний, кукурудзяні приймочки, pepper mint, піжмо, dog-rose, cholagol) Drugs which increase secretion of bile primarily due to water component (hydrocholeretics: mineral waters, valerian drugs) Drugs which stimulate bile secretion (cholekinetics) drugs which cause increasing of gall-bladder tone and decreasing of bile ducts tone (cholekinetics: magnesium sulfate, sorbit, barberries). drugs which cause increasing of gall-bladder tone and decreasing of bile ducts tone (cholekinetics: magnesium sulfate, sorbit, barberries). drugs which cause relaxation of bile ducts tone (cholespasmolytics: M-cholinoblockers, euphyllin, nitroglycerine). drugs which cause relaxation of bile ducts tone (cholespasmolytics: M-cholinoblockers, euphyllin, nitroglycerine).

30. Allochol (Allocholum)

31. Drugs of plant origin Кукурудзяніприймочки Безсмертникпіщаний Dog-rose

32. Cholagol

33. Pharmacodynamics of magnesium sulfate depending of way of administration

34. Clinical classification of antioxidants Antioxidants of direct action Drugs which contain vitamin E (tocopherole acetate, aevit). Vitamin C drugs (acrobatic acid, galascorbin, ascorutin). Bioflavonoids (legalon, flamin, flakumin, sylibor, convaflavin). Drugs which include thiol groups (unithiol, thiosulfate sodium). Antioxidants of indirect action Drugs which regulate phospholipid contents of cell membranes (essentiale, lipin, retinol, aevit). Precursors of pyridine nucleotides (nicotinic acid, nocotinamid). Precursors of glutation (metionin, cystein, glutamic acid). Drugs which induct glutationperoxydase (selenium containing drugs). Other drugs which increase antioxidating potential of blood and tissues (lipoic acid, lilamid, organic drugs of liver).

35. Tocopherole acetate (Tocopheroli acetas) Vitamin E is produced in many forms: 5 %, 10 % and 30 % oil solution in 10, 20 and 50 ml bottles; elastic capsules with 0,1 and 0,2 ml of 50 % solution in oil; ampoules with 1 ml of 5 %, 10 % and 30 % oil solutions.

36. Розтропша плямиста

37. CarsilLegalon

38. Mechanism of action of legalon

39. Essentiale Is produced in 5 ml ampoules and in capsules

40. Lipostabil

41. Pancreatin (Panсreatinum) Is produced in 0,25 g and 0,5 g dragee (tablets).

42. Panzynorm forte

43. Festal, Enzistal, Mezym-forte

44. No-spa, nicospan

45. Baralgin

46. Крушина звичайна

47. Bisakodil

48. Guttalax

49. Bil-berries St. John’s wort Bil-berries St. John’s wort

50. Pepper mint Chamomile Pepper mint Chamomile

51. Imodium