1. School of Medicine Shared Resource Facilities The School of Medicine provides direct support and oversight to 21 SOM shared resource facilities. Their purpose is to provide investigators within the Penn community access to scientific services widely required in the conduct of biomedical research but which are too costly for individual investigators or departments to bear. Oversight is provided by the School of Medicine Research Core Facilities Committee, which is led by an Associate Dean for Research Core Facilities.

2. Contributions of PSOM to Cores FY07FY08FY09FY10FY11FY12 Investments via Core Committee$250,000 Other Core Investments$700,000$300,000$312,428$420,585 $637,095 PSOM Support for Renovations$1,493,448$445,000 PSOM Support for Equipment$328,296$413,890$119,702$1,956,875 Total Expenditures$2,443,448$1,323,296$562,428$1,084,475$790,287$2,843,970

3. Reporting Structure Dean Perelman School of Medicine Office of Research Program Development Combined Degree and Physician Scholar ProgramsBiomedical Postdoctoral Programs Executive Vice Dean and Chief Scientific Officer Office of Corporate Alliances Global Health Programs Associate Dean for Research Core Facilities Morris J. Birnbaum, M.D., Ph.D. Biomedical Graduate Studies Office of Human Research Office of Masters Programs Research Planning and Management Executive Director: Education, Financial Planning and Management. Associate Dean for Research at the Philadelphia VA Medical Center Associate Dean for Translational Research Associate Dean for Research Program Development Senior Executive Director of Research & Research Training Assistant Dean for Animal Research Academic Support Programs

4. Research Core Facilities Committee 15 member committee representing various departments and areas of science Meets once a month Conducts reviews of core performance Evaluates core equipment and financial requests Requests an in-depth annual report every March Considers potential cores that should be developed

5. Cores Committee Members Morrie Birnbaum, IDOM Michael Feldman, Path & Lab Med Yale Goldman, Physiology Michael Granato, CDB Kate Nathanson, Medicine Nancy Speck, CDB Bob Vonderheide, Medicine John Wherry, Microbiology Admin Support: Dorothy Leung Perelman School of MedicineCHOP Tom Curran Wistar Bill Wunner Ex Officios Kathy Bramwell, Finance Susan Passante, EVD/CSO Brian Wells, IT & Research Computing Abramson Cancer Center Barbara Vance

6. Reviews and Requests Process Among the key considerations of the review process: Determine how valuable the to the community, both now and in the future Examine how well the Core is providingthe service Determine whether the Service is affordable to Penn PIs Consider ways to provide additional support

7. Biomedical Core Resources Behavioral Testing Unit Cell Center Services Cell Center Stockroom Clinical Cell and Vaccine Production Facility Clinical Research Computing Unit Confocal Core DNA Sequencing Facility Gene Targeting Service Electron Microscopy Core Flow Cytometry and Cell Sorting Research Lab Human Immunology Core Investigational Drug Service Molecular Profiling Core Next Generation Sequencing Proteomics and Systems Biology Core Research Instrumentation Shop Small Animal Imaging Facility Core Stem Cell and Xenograft Core Transgenic and Chimeric Mouse Core Translational Core Laboratory Vector Core Bio-banking Bioinformatics High throughout screening Current Medical School CoresCores in Development New Under review

8. www.med.upenn.edu/cores/

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10. Considerations in using Cores for large projects Is there sufficient money budgeted? Should there be funds for infrastructure? Does the Core have sufficient capacity? Can the Core supply necessary supporting material for grant application? Is the charge-back scheme compliant?

11. OMB Circular A-21