1. SEI IOP and its correlations in a population based study in Central India. The Central India Eye and Medical Study. Krishna Bhojwani, Vinay Nangia, Jost Jonas, Arshia Matin, Ajit Sinha and Maithili Kulkarni Suraj Eye institute, Nagpur - India

2. SEI Methods The Central India Eye and Medical Study (CIEMS) is a population based cohort study carried out in rural Central India. Out of total eligible 5885 individual 4711 participated in the study response rate 80.1%

3. SEI Methods Mean age 49.5 yrs median 47 yrs (range 30 -100 yrs) Out of 9422 eyes of 4711 subjects IOP measurements were available for 9338 eyes 99.5%

4. SEI Methods Complete ocular examination was done including ultasound CCT and Tonometry using Goldmann applanation tonometry. Eyes with scarred corneas were excluded from the study.

5. SEI Results Mean IOP was 13.6 ± 3.4mmHg (median 14.0 mmHg, range 2-56 mmHg). Mean CCT was 514 ± 33µm

6. SEI Results Ocular corelations –Higher corneal power ( p = 0.004) –Greater central corneal thickness ( p<0.001) –Higher myopic refractive power ( p=0.001)

7. SEI Results Systemic correlations –Diastolic BP ( p < 0.001) –Pulse rate ( p = 0.005) –Body mass index ( p = 0.001) Socioeconomic factors –Level of education ( p = 0,05) –Livestock ownership ( p = 0.08)

8. SEI Results of the multivariate analysis with IOP as dependent parameters and all parameters as independent parameters which were significantly associated with IOP in univariate analysis ParametersP-valueCoefficient B95% confidence interval of B Diastolic BP (mm Hg)<0.0010.050.04, 0.06 Pulse rate (beats/minute) 0.0050.02 0.01, 0.03 Body Mass Index0.010.050.02, 0.09 Level of Education0.050.150.05, 0.26 Cast0.0010.380.15, 0.62 Livestock Ownership0.008-0.18-0.32, -0.05 Corneal Refractive Power (Diopeters) 0.0040.120.04, 0.20 Central Corneal Thickness (um) <0.0010.020.02, 0.03 Refractive Error (Diopters) 0.001-0.13-0.21, -0.05 Gonioscopic data0.010.720.18, 1.26

9. SEI Histogram showing distribution of IOP in Central India Intraocular Pressure

10. SEI Discussion Mean and Median IOP measured in Central India was 14mmHg, following a Gaussian distribution curve. It is similar to the value reported from South India and slightly lower than studies done in Caucasians. It may be related to lower central corneal thickness measurements in our study.(514±33 μm)

11. SEI Discussion There was association of IOP with myopia in our study correlating with other studies. IOP and BP also has similar correlations as in other population based studies (Rotterdam Study) IOP was found to be associated with body mass index. It was not correlated with age.

12. SEI Summary Higher Intra Ocular Pressure were associated with Higher diastolic BP Higher pulse rate Higher body mass index Higher level of education Higher corneal refractive power Higher myopic refractive error and Greater central corneal thickness

13. SEI Thank You