1. Welcome to the Fall 2010 TBPT Meeting Dr. Paul Klotman President and CEO Baylor College of Medicine November 3, 2010

2. History of Baylor College of Medicine  Founded in 1900 in Dallas  Second oldest medical school in Texas  Moved to Houston in 1943  In 1947, moved to present site in Cullen Building – first building constructed in the Texas Medical Center  In 1969, the College separated from Baylor University to become an independent medical school

3. Baylor College of Medicine 1947 3

4. The Texas Medical Center Now 4

5. The University of Texas Health Science Center University of Houston Baylor University Harris County Hospital District Clinical and Academic Programs are Greatly Enhanced by Outstanding Affiliated and Collaborating Academic Institutions and Hospitals

6. America’s Best Graduate Schools Published by US News & World Report: 2011 Rankings Research Medical Schools: BCM #24 Graduate Schools: BCM #26 (out of over 400) Physician Assistant: BCM #9 Nurse Anesthesia: BCM #11

7. 7 Patient Care Baylor College of Medicine and its eight affiliated teaching hospitals are internationally recognized for medical excellence. Fifty percent of the patients cared for in the Texas Medical Center are treated by a Baylor physician. Texas Children’s Hospital DeBakey Veterans Affairs Medical Center Ben Taub General Hospital Memorial Hermann – The Institute for Rehabilitation & Research The Menninger Clinic St. Luke’s Episcopal Hospital M.D. Anderson Cancer Center The Methodist Hospital

8. 8 Multiple Specialty Centers for Research and Patient Care Dan L. Duncan Cancer CenterDan L. Duncan Cancer Center Lester & Sue Smith Breast Center Lester & Sue Smith Breast Center Diabetes and Endocrinology Research Center Diabetes and Endocrinology Research Center Human Genome Sequencing Center Human Genome Sequencing Center Huffington Center on Aging Huffington Center on Aging Center for Space Medicine Center for Space Medicine Center for Cell and Gene Therapy Center for Cell and Gene Therapy Stem Cells and Regenerative Medicine Center Stem Cells and Regenerative Medicine Center

9. 9 Source: National Science Foundation, February 2010 Research Federally Financed Research Expenditures Texas Colleges and Universities – FY 2008 State-wide NIH Grant Funding 2009 UT Austin BAYLOR COLLEGE OF MEDICINE Texas A&M University UT Southwestern UT M. D. Anderson UTHSC Houston UTMB Galveston UTHSC San Antonio Rice University University of Houston Texas A&M HSC UT El Paso UT San Antonio UT Dallas UT Arlington University of North Texas HSC Texas Tech University $324.3 million 262.5 million 245.6 million 201.5 million 194.9 million 129.3 million 122.0 million 121.8 million 55.0 million 43.2million 33.0 million 26.9 million 21.5 million 21.4 million 20.7 million 19.8 million 19.7 million $202.4 million 167.9 million 148.5 million 103.2 million 89.1 million 85.5 million 53.5 million 29.6 million 21.4 million 17.8 million 17.1 million 14.8 million 12.8 million 12.7 million 11.7 million 9.8 million 7.1 million 5.9 million BAYLOR COLLEGE OF MEDICINE UT Southwestern UT M.D. Anderson UTMB Galveston UTHSC Houston UTHSC San Antonio UT Austin SW Foundation for Biomedical Research Texas A&M- College Station Texas A&M HSC University of North Texas HSC University of Houston UT San Antonio Rice University UT El Paso Baylor Research Institute- Dallas Texas Tech University HSC UT Dallas

10. 10 Baylor College of Medicine Research Funding FY 2011 Federal funding $344 million Private/other funding $56 million Total Research funding $400 million

11. Dan L. Duncan Cancer Center at Baylor College of Medicine

12. Mission of the DLDCC Reduce suffering and mortality from cancer through research, education, patient care, and outreach into the community, especially the underserved.

13. DLDCC is a Matrix Center The Dan L. Duncan Cancer Center is comprised of: The Dan L. Duncan Cancer Center is comprised of:  Baylor College of Medicine – Scientific Leader  Clinical Affiliates  Ben Taub General Hospital  Michael E. DeBakey Veterans Affairs Medical Center  Texas Children's Hospital  Baylor Clinic

14. Dan L. Duncan Cancer Center Breast Center Center for Cell and Gene Therapy Stem Cell and Regenerative Medicine Center Genome Center Chemical Genomics Program Children’s Nutrition Research Center Rice, Methodist, MD Anderson breast pancreas liver colon lymphoma prostate leukemia brain Research Environment

15. Shared Resources  Biostatistics and Informatics  Cell Processing and Vector Production  Clinical Trials Support Unit  Flow Cytometry  Genetically Engineered Mouse  Genome-wide RNAi Screening and Analysis  Genomic Profiling  Human Tissue Acquisition/Pathology  Integrated Microscopy  Protein Expression/Proteomics  Population Sciences Bio-repository

16. Membership & Grant Support Research Members 189 Clinical Investigators 43 NCI Grants$44 million Other NIH$59 million Other peer review$10 million Industry$2 million Non peer review$11 million Total Cancer Funding $126 million

17. Cancer Prevention and Research Institute of Texas (CPRIT) A Remarkable Commitment of the State of Texas to Cancer Research; 3 Billion Dollars over 10 years A Remarkable Commitment of the State of Texas to Cancer Research; 3 Billion Dollars over 10 years Peer reviewed cancer research; 10% for education, prevention and screening Peer reviewed cancer research; 10% for education, prevention and screening Focus on multi-disciplinary and multi-institutional “statewide” initiatives; commercial potential Focus on multi-disciplinary and multi-institutional “statewide” initiatives; commercial potential In 2010, Baylor received more than $38 million in CPRIT funding In 2010, Baylor received more than $38 million in CPRIT funding

18. Research Programs 7 Cancer Center Support Grant Programs Cancer Biology Viral & Molecular Oncogenesis Nuclear Receptors Cancer Prevention & Population Sciences Cancer Cell & Gene Therapy Breast Cancer Pediatric Cancer Developing programs in Developing programs in Pancreas Cancer Pancreas Cancer Prostate Cancer Prostate Cancer Gastrointestinal Cancer Gastrointestinal Cancer

19. Clinical Trials  204 Therapeutic Clinical Trials Currently Open  59 of these are Investigator Initiated  13% of New Patients Accrued to Clinical Trials

20. Office of Outreach & Health Disparities  Screening programs with Harris County Hospital District  Inter-cultural Cancer Council  Texas Comprehensive Cancer Coalition  Physician Oncology Education Program  Partner with community organizations to address health disparities

21. Logos