1. HAPPY WEDNESDAY Bellwork Quickwrite: In 27 words, Which would more likely have a bigger effect on an organism, a point mutation or frameshift mutation?

2. mutation point frameshift protein frameshiftmutation pointprotein

3. If you have a mutation in a body cell (skin, stomach, bone, etc.), can you pass that mutation on to your children? Why or why not?

4. Do you know of any diseases caused by genetic mutations?

5. Sickle Cell Anemia These are the sickle-shaped blood cells of someone with sickle cell anemia. Sickle cell anemia is the result of a point mutation, a change in just one nucleotide in the gene for hemoglobin. This mutation causes the hemoglobin in red blood cells to distort to a sickle shape when deoxygenated. The sickle- shaped blood cells clog in the capillaries, cutting off circulation. Having two copies of the mutated genes cause sickle cell anemia, but having just one copy does not, and can actually protect against malaria - an example of how mutations are sometimes beneficial.

6. Color Blindness Most forms are caused by a point mutation on the X chromosome. What number do you see? A color blind person won’t see anything. A color deficient person may see the number 35

7. Achondroplasia This is the most common form of dwarfism. It is caused by a substitution mutation for the gene that codes for bone growth.