1. Institute of Cancer Research - Institut du cancer ICR’s Activities in Cancer Imaging

2. Institute of Cancer Research - Institut du cancer Funding Sources for Imaging Research in Canada Federal Canadian Institutes of Health Research (CIHR) Natural Science and Engineering Research Council (NSERC) Canadian Foundation for Innovation (CFI) National Research Council (NRC) Natural Resources Canada (NRCan) Canada Research Chairs (CRC) Canada Excellence Research Chairs (CERC) Networks of Centres of Excellence (NCE) Centres of Excellence for Commercialization and Research(CECR) Other Cancer – Canadian Cancer Research Alliance (CCRA) Provinces (Alberta Innovates, OICR); NGOs (CCS, TFRI)

3. CIHR  Created in 2000 to replace the Medical Research Council  CIHR is Canada’s federal funding agency for health research  CIHR’s mission is to create new scientific knowledge and to enable its translation into improved health, more effective health services and products, and a strengthened Canadian health care system.  CIHR supports more than 13,200 health researchers and trainees across Canada  CIHR funds both investigator-initiated research as well as research on targeted priority areas  CIHR builds research capacity in under-developed areas and training the next generation of health researchers  CIHR focuses on knowledge translation that facilitates the application of the results of research and their transformation into new policies, practices, procedures, products and services  CIHR operates with a $1 billion annual budget  CIHR has 13 virtual Institutes Institute of Cancer Research - Institut du cancer

4. Canadian Institutes of Health Research (CIHR)

5. In the beginning ……… Institute of Cancer Research - Institut du cancer

6. Bringing a community together

7. Outcomes of the first workshop Brought the oncology, cardiology and neurology imaging communities together Provided a series of recommendation for addressing the challenges in imaging Led to $10M, in Budget 2010, to support the first national imaging clinical trials network – MITNEC MITNEC now coordinating clinical trials on the new products produced in the Isotope initiative Institute of Cancer Research - Institut du cancer

8. Making International Connections

9. Imaging Workshop – Canada/US/UK Linking ‘omics to Patient care Through Imaging  The workshop was jointly organized by CIHR-ICR, NCI and CRUK and hosted by the Canadian High Commission in London, UK  The event brought together leading academic imaging and molecular science researchers from Canada (9); the UK (12); and the US (10), as well as organizing committee members, program staff and representatives of other UK research agencies  The goal of the workshop was to assess the feasibility of combining imaging expertise, resources and infrastructures among the three countries  The workshop included keynote presentations (two from each country); short presentations from participating researchers; a series of three breakout sessions; and informal networking opportunities  Discussions focused on finding common solutions to the existing barriers to translational research in cancer imaging Institute of Cancer Research - Institut du cancer

10. Key Recommendations from the Canada/US/UK Workshop The workshop generated great enthusiasm for the development of Canada/UK/US collaborations that could address an identified need to:  Optimize and validate innovative imaging platforms and methods that meet the sensitivity and specificity performance requirements for specific cancer problems  Provide robust quantitative measurements (as opposed to traditional qualitative methods), and optimize these methods for more efficient large-scale metadata analysis, and correlation with other research domains such as genomics, epigenetics, proteomics and other laboratory biomarker measurements.  Promote Interdisciplinary research in imaging and molecular sciences so more effective molecular or mechanistic-based solutions for data integration across the three imaging research domains can be explored and shared both nationally and internationally. Institute of Cancer Research - Institut du cancer

11. Development of a Management Plan Funding Opportunity: Quantitative Imaging for Prediction and/or Evaluation of Responses to Cancer Therapies The six-page Management Plan covered:  Goals of the program – establish two Canadian teams as an integral part of QIN  Program delivery model – submit directly to NIH  Funding opportunity announcement – CIHR website, NIH Guide for Grants and Contracts  Relevance review – NCI program staff, CIHR for eligibility check of applicant  Review of full applications – NIH and NCI policies and procedures, CIHR observer  QIN executive committee – CIHR representative on QIN Executive Committee  Communications – NCI and CIHR, French and English, for CIHR formal news releases through Canadian Minster of Health  Ownership of IP - awardees  Access to Information and privacy act - according to national regulations  Termination – provide notice in writing, meet to discuss future of program  Dispute resolution - resolved jointly by NCI and CIHR  Agreement non-legally binding  Collaboration  Contact information Institute of Cancer Research - Institut du cancer

12. Funding Opportunity: Quantitative Imaging for Prediction and/or Evaluation of Responses to Cancer Therapies  September 2013 - Alert imaging research community to the upcoming call  October 2013 – Post funding opportunity on CIHR website with links to the NIH websites  November 2013 – Webinex for interested researchers  Applications due February 2014  ICR, in partnership with Genome BC, will provide funding to support up to two Canadian QIN nodes for five years  Investment will be up to $400,000 per node per annum – this aligns well with the funding for the US nodes  Program will be run by the NIH through their regular processes.  The top two fundable Canadian applications will be funded Institute of Cancer Research - Institut du cancer

13. Canadian Participation in QIN As permitted under existing laws, regulations and policies the Canadian teams will participate in and contribute to:  QIN research activities  collaborative working groups  consensus publications  monthly teleconferences  annual and semi-annual meetings  other participatory activities of the Network Institute of Cancer Research - Institut du cancer

14. Going Forward Institute of Cancer Research - Institut du cancer

15. We’re growing!