1. 1 Clayton Biotechnologies, Inc. One Riverway, Suite 1520 Houston, Texas 77056 713.963.5860 www.claytonbiotech.com Overview of Clayton Biotechnologies, Inc.

2. 2 Clayton Biotechnologies, Inc. is a for-profit company which facilitates the commercialization of medical discoveries made by the Clayton Foundation for Research and its supporting entities. The Clayton Foundation for Research is a nonprofit medical research organization in Houston, Texas established in 1933 by Benjamin Clayton. The mission of the Foundation is two-fold: To transfer the resulting medical research discoveries from the laboratory to the use of the general public by patenting and licensing such technology for development into drugs or other products. To conduct medical research for the purpose of discovering the cause, prevention and cure of diseases for the benefit of mankind, and

3. 3 We conduct and fund medical research programs at leading universities, hospitals and academic institutions ■ Baylor College of Medicine ■ Baylor College of Medicine Texas Children's Cancer Center ■ North Carolina State University ■ Oregon Health and Science University ■ Salk Institute for Biological Studies ■ The University of Texas at Austin ■ The University of Texas Health Science Center at San Antonio ■ The University of Texas M.D. Anderson Cancer Center ■ The University of Texas Medical Branch at Galveston ■The University of Texas Southwestern Medical Center at Dallas ■ University of California, San Diego ■ University of Geneva

4. 4 Leading Researchers ANTIBODIES & ONCOLOGY ■George Georgiou ■Jordan Gutterman ■Stephen Howell ■Brent Iverson ■Beat Imhof ■Bert O’Malley ■Donald Parsons ■Michael Rosenblum ■Hongtao Yu METABOLIC DISEASES ■Marc Montminy ■David Russell CNS & OPHTHAMOLOGY ■Kuo-Fen Lee ■Karl-Heinz Krause ■Paul Sawchenko ■Tim Stout VIROLOGY and MICROBIOLOGY ■Dennis Brown and Raquel Hernandez ■Jere McBride and David Walker ■Haley Tucker and James Walker OTHER ■Marc Feldman and Thomas Milner ■David Corry

5. 5 Some of our start-up companies

6. 6 Some of our Other Licensees

7. 7 Products Brought to the Market Diagnostics SCA6 diagnostic tests Complete Ataxia Evaluation Therapeutics AccuPlex™4 test

8. 8 Collaboration and Licensing Opportunities Antibody targets for cancer: Grp78; Srpx2, Olmfl-3 Alk4-Fc, a Cripto antagonist for Cancer Granzyme B - a potent payload for antibody drug conjugates (ADC) Antibody Fc engineering: aglycosylated antibodies with potent and specific effector function Avicins, new class of triterpenes to treat cancer – IND approved package Filaggrin to treat dermatological disorders RTEF therapy for ocular neovascular disease Vaccines and Diagnostics for Ehrlichioses Synergistic activation of beta-islet cell production CRFR1 and CRFR2 agonists for Diabetes CRFR1 antagonists - therapeutic for early onset AD

9. 9 Please contact us! Clayton Biotechnologies, Inc. One Riverway, Suite 1520 Houston, Texas 77056 713.963.5860 www.claytonbiotech.com arichardson@claytonbiotech.com