1. NeSSI Compatible Spectroscopic Flow Cells
Mike Doyle Axiom Analytical, Inc.

2. Unique Requirements of Spectroscopic Process Analysis
Use of broad spectrum optical radiation
Need to couple to complex remote instruments
Need to produce SPC plots from large arrays of data

3. Comparison Of Four Forms Of Process Molecular Spectroscopy
Mid-IR
Near-IR
UV-Visible
Raman
Applicable Sampling Methods
ATR - liquids
Transmission - gases
Transmission
Diffuse reflectance
ATR
Raman Scattering
Band Types
Fundamentals
Overtones (CH, OH, etc)
Chromophores
Calibrations
Easy
Often Tedious
Case dependent
Optics
Chemically sensitive
Resilient
Fiber-Optic Coupling
Short Distances Only OK
Sample Fluorescence
Problematic
Background Radiation
Referencing

4. Applicability of Various Sampling Methods
Sample
Type
Mid-IR ATR
Mid-IR
Transmission
NIR & UV-Vis
NIR Diffuse
Reflectance
UV-Visible
ATR
Raman
Clear Fluids
Yes
Some Cases No
Scattering Fluids
Liquid Phase Only
Powders
Bulk Solids,
Scattering
Clear
Gases

5. Spectroscopic Methods Appropriate to the NeSSI Platform
Samples Type – Clear liquids
Methods:
Near-IR: Transmission
UV-Visible: Transmission and ATR
Raman: Backscatter
Mid-IR: ATR ?

6. The NeSSI Platform Objectives
Standardize and simplify systems for process analysis
Provide a system of miniature, interchangeable sample handling components
Analyzer systems close to the sampling point
Short lines, fast response
Modular assembly

7. Axiom Product Overview – Fluid Analysis Near-IR and UV-Visible Transmission
Established Products
FPT-850 Transmission Probes
FCT Series Cross-Line Sampling Systems
FFV-300 Series Transmission Cells
FST-500 Unistage Transmission Sampler
Most Significant Development
Permanent Welded-in Metal Seals
Recent Developments
Self Cleaning Probes
Small Diameter Probes
Polymer Melt Transmission Probes
NeSSI Compatible FFV Transmission Cells

8. FFV Series Transmission Cells
Variable or fixed pathlengths

9. FFV-320NSI Transmission Cell

10. FFV-320-NSI Transmission Cell

11. Tunable Laser Spectra of Isopropanol with Pathlengths from 1 to 7.5 mm

12. Comparison of FTIR and Tunable Laser Spectra (1 and 2 mm pathlengths)

13. Product Overview – Fluid Analysis Attenuated Total Reflectance (ATR)
Established Products
Direct-coupled ATR Probes – Including diamond tipped probes
ATR Flow Cells – Process and lab Tunnel Cells
Fiber-coupled UV-Visible Tunnel Cells
New Developments
Fiber-coupled Mid-IR ATR Probes
Integrated ATR Sampling Systems
UV-Visible ATR Probes (in development)
NeSSI Compatible UV-Visible Tunnel Cells

14. FNL-120 UV-Visible ATR Cell

15. Fiber-coupled UV-Visible Tunnel Cell

16. FNL-120EL Extended Length UV-Visible Tunnel Cell

17. FNL-120NSI UV-Visible ATR Cell

18. FNL-120UV-NSI UV-Visible ATR Cell

19. FNL-120EL Spectrum of 50% Red Food Dye

20. Product Overview Raman Probes
Established Products
Modular Raman Probes for Lab Applications – RFP-400 Series
Robust Process Probes – RFP-500 Series
Recent Developments
Self-cleaning Raman Probes
Multi-pass Raman Sampling
NeSSI Compatible Raman Cells (Single- and Multi-pass)

21. RFP-400 Series Lab Raman Probes

22. Multipass Raman Probe Design

23. NeSSI Multipass Raman Cell

24. Raman Spectra of Isopropanol: Black = single pass, Red = multipass, Blue = black X 8.4

25. Raman Spectra of Toluene: Black = single pass, Red = multipass, Blue = Black X8.0

26. NeSSI Sampling System Example

27. NeSSI Compatible Spectroscopic Cells from Axiom Analytical, Inc.
Currently Available
FFV Series Transmission Cells (Near-IR, UV-Visible)
FNL-120 UV-Visible ATR Cell
In Development
Raman Cells (Single- and Multi-pass)
Possible Development
Diffuse Reflectance Cells (For turbid liquids)
Mid-IR ATR Cells

28. Engineering for the Unexpected
Axiom Analytical, Inc.
Engineering for the Unexpected