1. The Technology THE MISSING LINK IN BIOPHARMACEUTICAL SCIENCES TM

2. “Anything that can be measured can be managed” A basic principle

3. AARDEX Advanced Analytical Research on Drug Exposure

4. Reliable assessment of drug exposure Single point in time assessment Continuous assessment over time Biased Pill counts Pharmacy refill data Patient diary Retrospective questionnaire Reliable Therapeutic drug monitoring (TDM) Electronic monitoring (EM) Vrijens & Urquhart, 2004 Journal of Antimicrobial Chemotherapy

5. The MEMS ® monitor The MEMS 6 monitor is an electronic cap that shows the number of openings since the start of the current 24-hour period and of hours elapsed since the last medication event. Stores up to 3800 medication events in non-volatile EEPROM memory Wireless data transfer, Fits standard pharmacy bottles 38mm-400 thread closure, Available with or without child resistant security, Unique serial number identification is indelibly printed on the monitor and stored in its electronic memory, Waterproof, CE marked, 18 months battery life.

6. Introducing advanced technology on monitoring adherence Medication Event Monitoring System (MEMS ® ) MEMS VI ® Events recording and storage Communicator MEMS VI ® Communication device www.viewcompliance.com Internet

7. Need a simple but robust taxonomy Our web-based platform Physician, Pharmacist Sion, Switzerland Anonymous, but drug-specific, aggregated database Individual reports back to Physician, Pharmacist FDA 21 CFR, 11 & HIPAA compliant Internet www.viewcompliance.com

8. Need a simple but robust taxonomy Log into the web compliance portal EN / FR / D version

9. Need a simple but robust taxonomy Individual compliance data report (forgetful patient)

10. Individual compliance data report (weekend effect)

11. Individual compliance data report (perfect patient)

12. Individual compliance data report (BID: evening variability)

13. Evolving Technology Over 400,000 patients monitored to date with the various version of MEMS (Medication Event Monitoring System) Currently used version (MEMS 6) has a proven track record on >140,000 patients >15,000 patients from controlled clinical trials with available data – Data on >3 Million monitoring days Ongoing device development: – MEMS 7 (Wireless) – Polypharmacy – Blister packaging MEMS 6 AARDEX®